Disruption of retinoid transport, metabolism and signaling by environmental pollutants

NOVÁK, Jiří, Martin BENÍŠEK and Klára HILSCHEROVÁ. Disruption of retinoid transport, metabolism and signaling by environmental pollutants. Environment International. Amsterdam, The Netherlands: Elsevier, 2008, vol. 34, No 6, p. 898-913. ISSN 0160-4120.

Basic information

Original name

Disruption of retinoid transport, metabolism and signaling by environmental pollutants

Name in Czech

Narušení transportu, metabolismu a signálování retinoidů kontaminanty životního prostředí

Authors

NOVÁK, Jiří (203 Czech Republic), Martin BENÍŠEK (203 Czech Republic) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor)

Edition

Environment International, Amsterdam, The Netherlands, Elsevier, 2008, 0160-4120

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.516

RIV identification code

RIV/00216224:14310/08:00025288

Organization unit

Faculty of Science

UT WoS

000259162000018

Keywords (in Czech)

vitamin A; all-trans retinonová kyselina; pesticidy; TCDD; polychlorované bifenyly; retinoidy

Keywords in English

vitamin A; all-trans retinoic acid; pesticide; TCDD; polychlorinated biphenyls; retinoids

Tags

all-trans retinoic acid, pesticide, Polychlorinated biphenyls, retinoids, TCDD, vitamin A

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Abstract

V originále

Disruption of retinoid transport, metabolism and signaling by environmental pollutants. - a review. Although the assessment of circulatory levels of retinoids has become a widely used biomarker of exposure to environmental pollutants, the adverse effects caused by imbalance of the retinoid metabolism and signaling in wildlife are not known in detail. Retinoids play an important role in controlling such vital processes as morphogenesis, development, reproduction or apoptosis. Unlike other signaling molecules, retinoids are not strictly endogenous but they are derived from dietary sources of vitamin A or its precursors and thus they are sometimes referred to as dietary hormones. Some environmental pollutants that affect embryogenesis, immunity or epithelial functions were also shown to interfere with retinoid metabolism and signaling in animals. This suggests that at least some of their toxic effects may be associated with interaction with the retinoid metabolism, transport or signal transduction. This review summarizes in vivo and in vitro studies on interaction of environmental complex samples, pesticides, polychlorinated dioxins, polychlorinated biphenyls, polycyclic aromatic compounds and other organic pollutants with metabolism and signaling of retinoids. It sums up contemporary knowledge about levels of interaction and mechanisms of action of the environmental contaminants.

In Czech

Narušení transportu, metabolismu a signálování retinoidů kontaminanty životního prostředí - review

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Links

GP525/05/P160, research and development project	Name: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů Investor: Czech Science Foundation, In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
MSM0021622412, plan (intention)	Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL) Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)