KUBÍKOVÁ, Iva, Hana KONEČNÁ, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Pavel ŘEHULKA, Hana HŘÍBKOVÁ, Helena ŘEHULKOVÁ, Aleš HAMPL, Josef CHMELÍK a Petr DVOŘÁK. Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin. Cytotherapy. United Kingdom, 2009, roč. 11, č. 3, s. 330-340. ISSN 1465-3249. Dostupné z: https://dx.doi.org/10.1080/14653240802595531. |
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@article{828562, author = {Kubíková, Iva and Konečná, Hana and Šedo, Ondrej and Zdráhal, Zbyněk and Řehulka, Pavel and Hříbková, Hana and Řehulková, Helena and Hampl, Aleš and Chmelík, Josef and Dvořák, Petr}, article_location = {United Kingdom}, article_number = {3}, doi = {http://dx.doi.org/10.1080/14653240802595531}, keywords = {human embryonic stem cell; hESC}, language = {eng}, issn = {1465-3249}, journal = {Cytotherapy}, title = {Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin}, url = {https://www.sciencedirect.com/science/article/pii/S1465324909702804?via%3Dihub}, volume = {11}, year = {2009} }
TY - JOUR ID - 828562 AU - Kubíková, Iva - Konečná, Hana - Šedo, Ondrej - Zdráhal, Zbyněk - Řehulka, Pavel - Hříbková, Hana - Řehulková, Helena - Hampl, Aleš - Chmelík, Josef - Dvořák, Petr PY - 2009 TI - Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin JF - Cytotherapy VL - 11 IS - 3 SP - 330-340 EP - 330-340 SN - 14653249 KW - human embryonic stem cell KW - hESC UR - https://www.sciencedirect.com/science/article/pii/S1465324909702804?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S1465324909702804?via%3Dihub N2 - Microvesicles (MVs) serve as mediators of cell-to-cell communication. However, they may also contain immunogenic domains or infectious particles acquired from xenogenic components of the culture milieu. Therefore, MVs represent a potential risk for the clinical application of cell therapy. We tested the ability of human embryonic stem cells (hESCs) to produce MVs. We found that hESCs are potent producers of MVs and we identified 5 unique protein species that are known to be highly expressed in invasive cancers and that participate in cellular activation, metastasis, and inhibition of apoptosis. Moreover, we found that hESC-derived MVs contain immunogenic agents apolipoprotein and transferrin, as well as mouse retroviral Gag protein. These findings highlight a potential danger of the clinical use of hESCs that have been previously exposed to animal proteins or cells. ER -
KUBÍKOVÁ, Iva, Hana KONEČNÁ, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Pavel ŘEHULKA, Hana HŘÍBKOVÁ, Helena ŘEHULKOVÁ, Aleš HAMPL, Josef CHMELÍK a Petr DVOŘÁK. Proteomic profiling of human embryonic stem cell-derived microvesicles reveals a risk of transfer of proteins of bovine and mouse origin. \textit{Cytotherapy}. United Kingdom, 2009, roč.~11, č.~3, s.~330-340. ISSN~1465-3249. Dostupné z: https://dx.doi.org/10.1080/14653240802595531.
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