Detailed Information on Publication Record
2009
Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa
YANG, Dong-Hwa, Ju-Young YOON, Soung-Hoon LEE, Vítězslav BRYJA, Emma R. ANDERSSON et. al.Basic information
Original name
Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase C alfa
Authors
YANG, Dong-Hwa (410 Republic of Korea), Ju-Young YOON (410 Republic of Korea), Soung-Hoon LEE (410 Republic of Korea), Vítězslav BRYJA (203 Czech Republic, guarantor), Emma R. ANDERSSON (752 Sweden), Ernest ARENAS (724 Spain), Young-Guen KWON (410 Republic of Korea) and Kang-Yell CHOI (410 Republic of Korea)
Edition
Circulation Research, 2009, 1524-4571
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 9.214
RIV identification code
RIV/00216224:14310/09:00028487
Organization unit
Faculty of Science
UT WoS
000263309900014
Keywords in English
Wnt5a; embryonic stem cells; beta-catenin; PKC alfa; endothelial defferentiation
Změněno: 28/3/2010 20:49, prof. Mgr. Vítězslav Bryja, Ph.D.
V originále
In this study, we examined the signaling pathways activated by Wnt5a in endothelial differentiation of embryonic stem (ES) cells and the function of Wnt5a during vascular development. We first found that Wnt5a(-/-) mouse embryonic stem (mES) cells exhibited a defect in endothelial differentiation, which was rescued by addition of Wnt5a, suggesting that Wnt5a is required for endothelial differentiation of ES cells. Furthermore, a defect in the vascularization of the neural tissue was detected at embryonic day 14.5 in Wnt5a(-/-) mice, implicating Wnt5a in vascular development in vivo. Thus, we conclude that Wnt5a is involved in the endothelial differentiation of ES cells via both Wnt/beta-catenin and PKC signaling pathways and regulates embryonic vascular development.
In Czech
V teto praci jsme studovali signalni drahy a vyznam proteinu Wnt5a v endotelialni diferenciaci. S pouzitim Wnt5a -/- embryonalnich kmenovych bunek a studiem Wnt5a-/- embryi dokazujeme, ze Wnt5a reguluje endotelialni diferenciaci pres Wnt/beta-katenin a PKC signalni drahy.
Links
| KJB501630801, research and development project |
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| MSM0021622430, plan (intention) |
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