BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ a Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. Německo: Springer, 2009, roč. 380, č. 2, s. 125-133. ISSN 0028-1298. |
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@article{831416, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Jansová, Dagmar and Šimurdová, Milena and Nováková, Marie and Šimurda, Jiří}, article_location = {Německo}, article_number = {2}, keywords = {perphenazine; antipsychotic drug; sodium current; transient outward current; rat ventricular myocytes}, language = {eng}, issn = {0028-1298}, journal = {Naunyn-Schmiedebergs Archives of Pharmacology}, title = {Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes}, volume = {380}, year = {2009} }
TY - JOUR ID - 831416 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Jansová, Dagmar - Šimurdová, Milena - Nováková, Marie - Šimurda, Jiří PY - 2009 TI - Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes JF - Naunyn-Schmiedebergs Archives of Pharmacology VL - 380 IS - 2 SP - 125-133 EP - 125-133 PB - Springer SN - 00281298 KW - perphenazine KW - antipsychotic drug KW - sodium current KW - transient outward current KW - rat ventricular myocytes N2 - Perphenazine reversibly blocked fast sodium current INa (reducing its amplitude; IC50 = 1.24 microM) and transient outward potassium current Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 microM, evaluated from changes of the time integral). Both blocks were use- and frequency-dependent at 3.3 Hz. Computer simulations suggest that perphenazine interacts preferentially with INa channels in inactivated states and with Ito channels in both open and open-inactivated states. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ a Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. \textit{Naunyn-Schmiedebergs Archives of Pharmacology}. Německo: Springer, 2009, roč.~380, č.~2, s.~125-133. ISSN~0028-1298.
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