Rad52 sumoylation affects the efficiency of the recombination and repair

KREJČÍ, Lumír. Rad52 sumoylation affects the efficiency of the recombination and repair. Kréta, Řecko: DNA Repair, 2009.

Basic information

Original name

Rad52 sumoylation affects the efficiency of the recombination and repair

Name in Czech

SUMOylace Rad52 proteinu ovlivnuje ucinnost rekombinace a DNA opravy

Authors

KREJČÍ, Lumír

Edition

Kréta, Řecko, 2009

Publisher

DNA Repair

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Other information

Language

English

Type of outcome

Audiovisual works

Field of Study

10600 1.6 Biological sciences

Country of publisher

Italy

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Marked to be transferred to RIV

No

Organization unit

Faculty of Medicine

Keywords in English

DNA repair; DNA damage; replication; genomic instability

Tags

DNA damage, DNA repair, genomic instability, replication

Tags

International impact

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Abstract

In the original language

Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.

In Czech

Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.

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Links

GA301/09/1917, research and development project	Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu Investor: Czech Science Foundation
GD203/09/H046, research and development project	Name: Biochemie na rozcestí mezi in silico a in vitro Investor: Czech Science Foundation
LC06030, research and development project	Name: Biomolekulární centrum Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)	Name: Proteiny v metabolismu a při interakci organismů s prostředím Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment