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@inproceedings{832396,
author = {Havelková, Marie and Unger, Eberhard},
address = {Slovensko},
booktitle = {37th Annual Conference on Yeasts.},
edition = {1},
keywords = {Yeast Cell - cytostatics - cell cycle - mitosis - nuclear division - microtubular cytoskeleton - actin filaments - calmodulin - cell senescence},
language = {eng},
location = {Slovensko},
publisher = {Chemický ústav SAV Bratislava},
title = {YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS},
year = {2009}
}
TY - JOUR
ID - 832396
AU - Havelková, Marie - Unger, Eberhard
PY - 2009
TI - YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS
PB - Chemický ústav SAV Bratislava
CY - Slovensko
KW - Yeast Cell - cytostatics - cell cycle - mitosis - nuclear division - microtubular cytoskeleton - actin filaments - calmodulin - cell senescence
N2 - Three selected yeast strains of Yarrowia lipolytica species were used as modelling objects to test 62 chemical substances considered to be potentional cytostatics. In the cells following phenomena were observed and analysed: 1/ process of cell cycle, 2/ process of mitosis, 3/ morphology of nucleus, formation of polynuclear forms, 3/ amount of DNA in nucleus, polyploid nuclei formation, 4/ localization, morphology of microtubular cytoskeleton, 5/ amount and localization of actin microfilaments, 6/ presence, amount and localization of calmodulin. Six of all analysed substances were found to be appropriate (as cytostatics) and were suggested for a further detailed analysis.
ER -
HAVELKOVÁ, Marie a Eberhard UNGER. YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS. In \textit{37th Annual Conference on Yeasts.}. 1. vyd. Slovensko: Chemický ústav SAV Bratislava, 2009, 80 s. ISSN~1336-4839.
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