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@inproceedings{832437,
author = {Šulák, Ondřej and Delia, Monia and Cioci, Gianluca and Varrot, Annabelle and Imberty, Anne and Wimmerová, Michaela},
address = {Brno},
booktitle = {Cukrblik 2009},
keywords = {Superlectin; X ray; Isothermal titration callorimetry; Burkolderia cenocepacia},
language = {eng},
location = {Brno},
isbn = {978-80-210-4831-7},
pages = {28-87},
publisher = {Masarykova univerzita},
title = {Novel two - domain superlectin from the human opportunistic pathogen Bukholderia cenocepacia},
year = {2009}
}
TY - JOUR
ID - 832437
AU - Šulák, Ondřej - Delia, Monia - Cioci, Gianluca - Varrot, Annabelle - Imberty, Anne - Wimmerová, Michaela
PY - 2009
TI - Novel two - domain superlectin from the human opportunistic pathogen Bukholderia cenocepacia
PB - Masarykova univerzita
CY - Brno
SN - 9788021048317
KW - Superlectin
KW - X ray
KW - Isothermal titration callorimetry
KW - Burkolderia cenocepacia
N2 - Lectins are known for their ability to agglutinate erythrocytes in vitro. Plant and animal pathogens use these protein-carbohydrate interactions in their strategy for host recognition and invasion. Burkholderia cenocepacia is a Gram-negative bacterium that can be found throughout the environment.Four genes coding protein homologues to the lectin PA-IIL from Pseudomonas aeruginosa have been found in the genome of B. cenocepacia. One of them, BclC, is a 28 kDa protein. Further sequence analysis showed two distinct domains in the protein structure. The C-terminal part coding lectin domain shows partial homology to the PA-IIL lectin, as mentioned above, and the N-terminal part is unknown. Both domains were also cloned separately. The results indicated the unusual binding activity of the protein. The C-terminal domain recognizes D-mannosylated saccharides with high affinity. Interestingly, the N-terminal domain also displays sugar-binding activity with a strong preference for L-fucosylated oligosaccharides, the Lewis type determinants.
ER -
ŠULÁK, Ondřej, Monia DELIA, Gianluca CIOCI, Annabelle VARROT, Anne IMBERTY a Michaela WIMMEROVÁ. Novel two - domain superlectin from the human opportunistic pathogen Bukholderia cenocepacia. In \textit{Cukrblik 2009}. Brno: Masarykova univerzita, 2009, s.~28-87. ISBN~978-80-210-4831-7.
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