Genotypes-by-nutrient associations of common polymorphisms in
obesity-related genes within the Czech population

D 2009

Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Martin VAVŘINA et. al.

Basic information

Original name

Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population

Name in Czech

Genotyp-fenotypové interakce v populaci četných polymorfismů v genech kódujících adipokiny v české populaci

Authors

Edition

209. vyd. Vídeň, Rakousko, European Journal of Human Genetics, suppl. p. 252-252, 1 pp. 2009

Publisher

European Society of Human Genetics

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

Genetics and molecular biology

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords (in Czech)

adipokiny; polymorfismus; složení stravy; genotyp; nutrient

Keywords in English

adipokine; polymorphism; dietary composition; genotype; nutrient

Abstract

ORIG CZ

V originále

INTRODUCTION: The personal food preferences can either enhance or suppress the development of obesity and the selection and proportion of macronutrients in the diet seems to have a heritable component. In this study, we therefore focused on dietary composition as a specific trait related to obesity and we determined, whether genetic variations in leptin (LEP), leptin receptor (LEPR), ghrelin (GHRL), adiponectin (ADIPOQ), interleukin 6 (IL6), proopiomelanocortin (POMC) and melanocortin-4 receptor (MC4R) underlie specific native food preferences and obesity-realated anthropometric parameters. METHODS: The total of 409 individuals of Czech Caucasian origin were enrolled into this study and the 7-day food records and parallel 7-day records of physical activity were obtained from the study subject as well as anthropometric measurements. In a subset of study subjects, plasma levels of adiponectin, leptin and soluble leptin receptor were measured. RESULTS: Independenty on the BMI of the individuals, common variations in leptin and leptin receptor genes were associated with specific eating patterns, mainly with respect to timing of eating. Diastolic blood pressure was significantly associated with the common variation in the leptin receptor gene as well as with the ratio of soluble leptin receptor and leptin plasma levels. In multivariate analysis, common variations in LEP, LEPR, POMC and MC4R genes expressed an independent prediction role for percentage of body fat. DISCUSSION: To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence time structure of food intake during the day.

In Czech

Identifikovali jsme řadu SNPs v kandidátních genech pro obezitu, které jsou asociovány se specifickými vzorci stravování, složením stravy a antropometrickými parametry souvisejícími s obezitou.

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Martin VAVŘINA, Jana KUDĚLKOVÁ, Monika CHMELÍKOVÁ, Kateřina HECZKOVÁ, Zlata PISKÁČKOVÁ, Lenka KUČEROVÁ, Zuzana DERFLEROVÁ BRÁZDOVÁ and Anna VAŠKŮ. Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population. In European Journal of Human Genetics, suppl. 209th ed. Vídeň, Rakousko: European Society of Human Genetics, 2009, p. 252-252.

@inproceedings{832755,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Forejt, Martin and Tomandl, Josef and Vavřina, Martin and Kudělková, Jana and Chmelíková, Monika and Heczková, Kateřina and Piskáčková, Zlata and Kučerová, Lenka and Derflerová Brázdová, Zuzana and Vašků, Anna},
   address = {Vídeň, Rakousko},
   booktitle = {European Journal of Human Genetics, suppl.},
   edition = {209},
   keywords = {adipokine; polymorphism; dietary composition; genotype; nutrient},
   language = {eng},
   location = {Vídeň, Rakousko},
   pages = {252-252},
   publisher = {European Society of Human Genetics},
   title = {Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population},
   year = {2009}
}

TY  - JOUR
ID  - 832755
AU  - Bienertová Vašků, Julie - Bienert, Petr - Forejt, Martin - Tomandl, Josef - Vavřina, Martin - Kudělková, Jana - Chmelíková, Monika - Heczková, Kateřina - Piskáčková, Zlata - Kučerová, Lenka - Derflerová Brázdová, Zuzana - Vašků, Anna
PY  - 2009
TI  - Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population
PB  - European Society of Human Genetics
CY  - Vídeň, Rakousko
KW  - adipokine
KW  - polymorphism
KW  - dietary composition
KW  - genotype
KW  - nutrient
N2  - INTRODUCTION: The personal food preferences can either enhance or suppress the development of obesity and the selection and proportion of macronutrients in the diet seems to have a heritable component. In this study, we therefore focused on dietary composition as a specific trait related to obesity and we determined, whether genetic variations in leptin (LEP), leptin receptor (LEPR), ghrelin (GHRL), adiponectin (ADIPOQ), interleukin 6 (IL6), proopiomelanocortin (POMC) and melanocortin-4 receptor (MC4R) underlie specific native food preferences and obesity-realated anthropometric parameters. METHODS: The total of 409 individuals of Czech Caucasian origin were enrolled into this study and the 7-day food records and parallel 7-day records of physical activity were obtained from the study subject as well as anthropometric measurements. In a subset of study subjects, plasma levels of adiponectin, leptin and soluble leptin receptor were measured. RESULTS: Independenty on the BMI of the individuals, common variations in leptin and leptin receptor genes were associated with specific eating patterns, mainly with respect to timing of eating. Diastolic blood pressure was significantly associated with the common variation in the leptin receptor gene as well as with the ratio of soluble leptin receptor and leptin plasma levels. In multivariate analysis, common variations in LEP, LEPR, POMC and MC4R genes expressed an independent prediction role for percentage of body fat. DISCUSSION: To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence time structure of food intake during the day.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Martin VAVŘINA, Jana KUDĚLKOVÁ, Monika CHMELÍKOVÁ, Kateřina HECZKOVÁ, Zlata PISKÁČKOVÁ, Lenka KUČEROVÁ, Zuzana DERFLEROVÁ BRÁZDOVÁ and Anna VAŠKŮ. Genotypes-by-nutrient associations of common polymorphisms in obesity-related genes within the Czech population. In \textit{European Journal of Human Genetics, suppl.}. 209th ed. Vídeň, Rakousko: European Society of Human Genetics, 2009, p.~252-252.

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