DEL TORO, Miguel, Pavel BUČEK, Anna AVIÑÓ, Joaquim JAUMOT, Carlos GONZALES, Ramon ERITJA and Raimundo GARGALLO. Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and the complementary C-rich strand. Biochimie. Paris: Elsevier Masson SAS, 2009, vol. 91, No 7, p. 894-902. ISSN 0300-9084. |
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@article{834828, author = {del Toro, Miguel and Buček, Pavel and Aviñó, Anna and Jaumot, Joaquim and Gonzales, Carlos and Eritja, Ramon and Gargallo, Raimundo}, article_location = {Paris}, article_number = {7}, keywords = {Oligonucleotides;G_quadruplex; bcl-2;TMPyP4;Spectroscopy;Multivariate analysis}, language = {eng}, issn = {0300-9084}, journal = {Biochimie}, title = {Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and the complementary C-rich strand}, url = {http://www.sciencedirect.com/science/article/pii/S0300908409001126}, volume = {91}, year = {2009} }
TY - JOUR ID - 834828 AU - del Toro, Miguel - Buček, Pavel - Aviñó, Anna - Jaumot, Joaquim - Gonzales, Carlos - Eritja, Ramon - Gargallo, Raimundo PY - 2009 TI - Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and the complementary C-rich strand JF - Biochimie VL - 91 IS - 7 SP - 894-902 EP - 894-902 PB - Elsevier Masson SAS SN - 03009084 KW - Oligonucleotides;G_quadruplex KW - bcl-2;TMPyP4;Spectroscopy;Multivariate analysis UR - http://www.sciencedirect.com/science/article/pii/S0300908409001126 N2 - The interaction of BCL-2 G-quadruplex forming sequence with cationic porphyrin TMPyP4 and its C-rich complementary strand was studied by means of molecular absorption spectroscopy and circular dichroism, experimental dates were analysed by advanced chemometric techniques based on mulitvariate analysis. Analyses resulted in proving 1:2 stoichiometry for the complex BCL-2G:TMPyP4 and equilibrium constant 5,0*10^13 M-2, that is weaker than complex of BCL-2 complementary strands, equilibrium constant of which was determined 10^7,7 M-1. ER -
DEL TORO, Miguel, Pavel BUČEK, Anna AVIÑÓ, Joaquim JAUMOT, Carlos GONZALES, Ramon ERITJA and Raimundo GARGALLO. Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and the complementary C-rich strand. \textit{Biochimie}. Paris: Elsevier Masson SAS, 2009, vol.~91, No~7, p.~894-902. ISSN~0300-9084.
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