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@proceedings{835429,
author = {Kovářová, Lucie and Burešová, Ivana and Muthu Raja, Karthick Raja and Penka, Miroslav and Hájek, Roman},
booktitle = {14th Congress of the European Hematology Association},
keywords = {plasma cells; CD27; multiple myeloma; flow cytometry},
language = {eng},
isbn = {ISSN 0390-6078},
title = {Expression of CD27 on plasma cells in multiple myeloma},
url = {http://online.haematologica.org/EHA14/index.php},
year = {2009}
}
TY - CONF
ID - 835429
AU - Kovářová, Lucie - Burešová, Ivana - Muthu Raja, Karthick Raja - Penka, Miroslav - Hájek, Roman
PY - 2009
TI - Expression of CD27 on plasma cells in multiple myeloma
SN - ISSN 03906078
KW - plasma cells
KW - CD27
KW - multiple myeloma
KW - flow cytometry
UR - http://online.haematologica.org/EHA14/index.php
N2 - Multiple myeloma (MM) is characterised by a clonal expansion of neoplastic plasma cells (PC). These PCs are mostly CD19-CD56+, but in a small group of patients clonal CD19+ PCs occur. The aim of this study was to analyse expression of CD27 on CD19+ PCs in different groups of MM patients and to prove that CD27 can be routinely used to confirm polyclonality of CD19+ PCs. In group of 5 patients with clonal CD19+ PCs was the correlation between median of CD19+CD56- PCs and CD19+CD27+ PCs significantly lower (0.36) than in group 55 patients with polyclonal CD19+ PCs (0.96). In our hands expression of CD27 on CD19+ PCs can discriminate between clonal and polyclonal CD19+ PCs and thus can be potentially used instead of labour intensive light chains assessment.
ER -
KOVÁŘOVÁ, Lucie, Ivana BUREŠOVÁ, Karthick Raja MUTHU RAJA, Miroslav PENKA a Roman HÁJEK. Expression of CD27 on plasma cells in multiple myeloma. In \textit{14th Congress of the European Hematology Association}. 2009. ISSN~0390-6078.
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