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@inproceedings{835632,
author = {Jálová, Veronika and Hilscherová, Klára and Giesy, John P. and Ocelka, Tomáš and Grabic, Roman and Jurčíková, Jana},
address = {Warsaw, Poland},
booktitle = {Abstract Book - SETAC Europe 18th Annual Meeting},
keywords = {(anti)androgenicity; (anti)estrogenicity; in vitro bioassays; passive sampling},
language = {eng},
location = {Warsaw, Poland},
pages = {147-147},
publisher = {Society of Environmental Toxicology and Chemistry Europe},
title = {Complex assessment of endocrine disruptive activity in the river ecosystem using active and passive sampling and bioassays},
year = {2008}
}
TY - JOUR
ID - 835632
AU - Jálová, Veronika - Hilscherová, Klára - Giesy, John P. - Ocelka, Tomáš - Grabic, Roman - Jurčíková, Jana
PY - 2008
TI - Complex assessment of endocrine disruptive activity in the river ecosystem using active and passive sampling and bioassays
PB - Society of Environmental Toxicology and Chemistry Europe
CY - Warsaw, Poland
KW - (anti)androgenicity
KW - (anti)estrogenicity
KW - in vitro bioassays
KW - passive sampling
N2 - The aim of this study is the interconnecting of chemical and biological monitoring to obtain complex characterization of contamination in the aquatic environment, focused especially on endocrine disruptive (ED) activity. The study has been conducted in a region of city agglomeration in Central Europe with 400,000 inhabitants and many industrial activities. Multiple types of integrative passive samplers have been used to detect presence of contaminants with ED-potential in water - SPMD (Semi-Permeable Membrane Devices) and POCIS (Polar Organic Chemical Integrative Sampler) for polar pesticides and pharmaceuticals. Battery of in vitro bioassays has been used to assess contamination by compounds with specific modes of action in water, sediments and fish tissue extracts. The bioassays with recombinant yeast and cell systems have been used to evaluate cytotoxic, dioxin-like, (anti)estrogenic and (anti)androgenic potency. The complex approach enabled to assess the presence and distribution of compounds with specific mode of action in various components of the river ecosystem as well as elucidate the character ED-active compounds in the river water. The project has been supported by MSMT 2B06093 and INCHEMBIOL 0021622412.
ER -
JÁLOVÁ, Veronika, Klára HILSCHEROVÁ, John P. GIESY, Tomáš OCELKA, Roman GRABIC a Jana JURČÍKOVÁ. Complex assessment of endocrine disruptive activity in the river ecosystem using active and passive sampling and bioassays. In \textit{Abstract Book - SETAC Europe 18th Annual Meeting}. Warsaw, Poland: Society of Environmental Toxicology and Chemistry Europe, 2008, s.~147.
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