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@article{835941,
author = {Kopecká, Marie and Gabriel, Miroslav},
article_location = {Basel, Switzerland},
article_number = {4},
keywords = {Yeast;Actin;Microtubules;Paclitaxel;Vincristine;Vinblastine;Methyl benzimidazole2yl carbamate;Thiabendazole; Cytochalasins A B D; Latrunculin A},
language = {eng},
issn = {0009-3157},
journal = {CHEMOTHERAPY},
title = {Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals},
url = {http://www.karger.com/che},
volume = {55},
year = {2009}
}
TY - JOUR
ID - 835941
AU - Kopecká, Marie - Gabriel, Miroslav
PY - 2009
TI - Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals
JF - CHEMOTHERAPY
VL - 55
IS - 4
SP - 278-286
EP - 278-286
PB - S. KARGER AG, Basel
SN - 00093157
KW - Yeast;Actin;Microtubules;Paclitaxel;Vincristine;Vinblastine;Methyl benzimidazole2yl carbamate;Thiabendazole
KW - Cytochalasins A B D
KW - Latrunculin A
UR - http://www.karger.com/che
N2 - The cytoskeleton was investigated as a potential target for the inhibition of cell division in Fellomyces fuzhou-ensis related to Cryptococcus neoformans.Vincristine, vinblastine,paclitaxel,methyl benzimidazole-2-yl carbamate (BCM),thiabendazole,cytochalasins A,B,D and latrunculin A were added to cells and investigated.Vincristine, vinblastine, paclitaxel, cytochalasins A,B and D transiently blocked proliferation. BCM disrupted microtubules,inhibited mitosis, but F-actin structures persisted and neck-less conidia originated. Latrunculin disrupted F-actin, cells became spherical,stalks and necks degenerated, microtubules persisted,mitosis,cytokinesis and conidiogenesis were blocked.The combined application of latrunculin and BCM disrupted F-actin and microtubules,inhibited cells became spherical and did not divide.Conclusion: Microtubules and F-actin are effective targets for permanent inhibition of nuclear and cell division and conidiogenesis by BCM and latrunculin A.
ER -
KOPECKÁ, Marie a Miroslav GABRIEL. Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals. \textit{CHEMOTHERAPY}. Basel, Switzerland: S. KARGER AG, Basel, 2009, roč.~55, č.~4, s.~278-286. ISSN~0009-3157.
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