| HAMAL, Petr, Jiří OSTRANSKY, Miloš DENDIS, Radek HORVÁTH, Filip RŮŽIČKA, Vladimír BUCHTA, Marcela VEJŠOVÁ, Pavel SAUER, Petr HEJNAR and Vladislav RACLAVSKÝ. A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. Medical Mycology. Oxford, U.K.: Blackwell Science, 2008, vol. 46, No 6, p. 601-605. ISSN 1369-3786. |
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@article{836844,
author = {Hamal, Petr and Ostransky, Jiří and Dendis, Miloš and Horváth, Radek and Růžička, Filip and Buchta, Vladimír and Vejšová, Marcela and Sauer, Pavel and Hejnar, Petr and Raclavský, Vladislav},
article_location = {Oxford, U.K.},
article_number = {6},
keywords = {INFECTIVE ENDOCARDITIS; HANSENULA-ANOMALA; CROSS-RESISTANCE; CANDIDA; IDENTIFICATION; FUNGEMIA; THERAPY; VORICONAZOLE; CASPOFUNGIN; DIAGNOSIS},
language = {eng},
issn = {1369-3786},
journal = {Medical Mycology},
title = {A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment},
volume = {46},
year = {2008}
}
TY - JOUR
ID - 836844
AU - Hamal, Petr - Ostransky, Jiří - Dendis, Miloš - Horváth, Radek - Růžička, Filip - Buchta, Vladimír - Vejšová, Marcela - Sauer, Pavel - Hejnar, Petr - Raclavský, Vladislav
PY - 2008
TI - A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment
JF - Medical Mycology
VL - 46
IS - 6
SP - 601-605
EP - 601-605
PB - Blackwell Science
SN - 13693786
KW - INFECTIVE ENDOCARDITIS
KW - HANSENULA-ANOMALA
KW - CROSS-RESISTANCE
KW - CANDIDA
KW - IDENTIFICATION
KW - FUNGEMIA
KW - THERAPY
KW - VORICONAZOLE
KW - CASPOFUNGIN
KW - DIAGNOSIS
N2 - Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
ER -
HAMAL, Petr, Jiří OSTRANSKY, Miloš DENDIS, Radek HORVÁTH, Filip RŮŽIČKA, Vladimír BUCHTA, Marcela VEJŠOVÁ, Pavel SAUER, Petr HEJNAR and Vladislav RACLAVSKÝ. A case of endocarditis caused by the yeast Pichia fabianii with biofilm production and developed in vitro resistance to azoles in the course of antifungal treatment. \textit{Medical Mycology}. Oxford, U.K.: Blackwell Science, 2008, vol.~46, No~6, p.~601-605. ISSN~1369-3786.
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