Anti-IgA antibodies in Common Variable Immunodeficiency (CVID):
Diagnostic workup and therapeutic strategy

J 2007

Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ et. al.

Základní údaje

Originální název

Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy

Název česky

Anti-IgA protilátky u běžné variabilní imunodeficience (CVID): vypracování diagnostické a terapeutické strategie

Autoři

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER a B. GRIMBACHER

Vydání

CLINICAL IMMUNOLOGY, 2007, 1521-6616

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.551

Organizační jednotka

Lékařská fakulta

UT WoS

000243779300006

Klíčová slova česky

IgG anti IgA protilátky; běžná variabilní imunodeficience (CVID); IgA deficit

Klíčová slova anglicky

IgG anti IgA antibodies; Common Variable Immunodeficiency (CVID); IgA deficiency

Štítky

Common Variable Immunodeficiency (CVID), IgA deficiency, IgG anti IgA antibodies

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2009 12:10, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely tacked IgA (< 0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To identify predisposing factors for anti-IgA antibodies and related anaphytactoid reactions, we analyzed the clinical and immunological phenotype of affected patients. All eight IgG anti-IgA-positive patients tacked IgA(+) B cells in peripheral blood. Moreover, CVID patients with retained class-switched CD27(pos) IgM(neg) IgD(neg) memory B cells (Freiburg classification group II) and total IgA deficiency seem to have an increased risk for developing anti-IgA antibodies. In seven of the eight patients, lymphoproliferation was observed (most prominently nodular lymphatic hyperplasia), two had granulomatous disease, and two showed autoimmune phenomena.

Česky

Anti-IgA protilátky u běžné variabilní imunodeficience (CVID): vypracování diagnostické a terapeutické strategie.

Návaznosti

NR9035, projekt VaV

Název: Specifická protilátková odpověď u pacientů s poruchami imunity

Citovat

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER a B. GRIMBACHER. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. CLINICAL IMMUNOLOGY. 2007, roč. 122, č. 2, s. 156-162. ISSN 1521-6616.

@article{837046,
   author = {Horn, J. and Thon, Vojtěch and Bartonkova, D. and Salzer, U. and Warnatz, K. and Schlesier, M. and Peter, HH. and Grimbacher, B.},
   article_number = {2},
   keywords = {IgG anti IgA antibodies; Common Variable Immunodeficiency (CVID); IgA deficiency},
   language = {eng},
   issn = {1521-6616},
   journal = {CLINICAL IMMUNOLOGY},
   title = {Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy},
   volume = {122},
   year = {2007}
}

TY  - JOUR
ID  - 837046
AU  - Horn, J. - Thon, Vojtěch - Bartonkova, D. - Salzer, U. - Warnatz, K. - Schlesier, M. - Peter, HH. - Grimbacher, B.
PY  - 2007
TI  - Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy
JF  - CLINICAL IMMUNOLOGY
VL  - 122
IS  - 2
SP  - 156-162
EP  - 156-162
SN  - 15216616
KW  - IgG anti IgA antibodies
KW  - Common Variable Immunodeficiency (CVID)
KW  - IgA deficiency
N2  - Common Variable Immunodeficiency (CVID) patients who are seropositive for anti-IgA antibodies have a predisposition for anaphylactoid reactions to intravenous immunoglobulin replacement therapy (IVIG). Among 88 CVID patients, we identified eight with IgG anti-IgA antibodies (9%). All eight completely tacked IgA (< 0.0009 g/l). Five of them had a history of anaphylactoid reactions to IVIG. However, four of these five patients tolerated subcutaneous immunoglobulin replacement therapy (SCIG). To identify predisposing factors for anti-IgA antibodies and related anaphytactoid reactions, we analyzed the clinical and immunological phenotype of affected patients. All eight IgG anti-IgA-positive patients tacked IgA(+) B cells in peripheral blood. Moreover, CVID patients with retained class-switched CD27(pos) IgM(neg) IgD(neg) memory B cells (Freiburg classification group II) and total IgA deficiency seem to have an increased risk for developing anti-IgA antibodies. In seven of the eight patients, lymphoproliferation was observed (most prominently nodular lymphatic hyperplasia), two had granulomatous disease, and two showed autoimmune phenomena.
ER  -

HORN, J., Vojtěch THON, D. BARTONKOVA, U. SALZER, K. WARNATZ, M. SCHLESIER, HH. PETER a B. GRIMBACHER. Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. \textit{CLINICAL IMMUNOLOGY}. 2007, roč.~122, č.~2, s.~156-162. ISSN~1521-6616.

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