| KUBA, Robert, Milan BRÁZDIL, Miroslav KALINA, Tomáš PROCHÁZKA, Jiří HOVORKA, Tomáš NEŽÁDAL, Jan HADAČ, Klára BROŽOVÁ, Věra SEBROŇOVÁ, Vladimír KOMÁREK, Petr MARUSIČ, Hana OŠLEJŠKOVÁ, Jana ZARUBOVA and Ivan REKTOR. Vagus nerve stimulation: Longitudinal follow-up patients treated for 5 years. Seizure. 2009, vol. 18, No 4, p. 269-274. ISSN 1059-1311. Available from: https://dx.doi.org/10.1016/j.seizure.2008.10.012. |
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@article{837053,
author = {Kuba, Robert and Brázdil, Milan and Kalina, Miroslav and Procházka, Tomáš and Hovorka, Jiří and Nežádal, Tomáš and Hadač, Jan and Brožová, Klára and Sebroňová, Věra and Komárek, Vladimír and Marusič, Petr and Ošlejšková, Hana and Zarubova, Jana and Rektor, Ivan},
article_number = {4},
doi = {http://dx.doi.org/10.1016/j.seizure.2008.10.012},
keywords = {vagus nerve stimulation; efficacy; long-term outcome; comlications},
language = {eng},
issn = {1059-1311},
journal = {Seizure},
title = {Vagus nerve stimulation: Longitudinal follow-up patients treated for 5 years.},
volume = {18},
year = {2009}
}
TY - JOUR
ID - 837053
AU - Kuba, Robert - Brázdil, Milan - Kalina, Miroslav - Procházka, Tomáš - Hovorka, Jiří - Nežádal, Tomáš - Hadač, Jan - Brožová, Klára - Sebroňová, Věra - Komárek, Vladimír - Marusič, Petr - Ošlejšková, Hana - Zarubova, Jana - Rektor, Ivan
PY - 2009
TI - Vagus nerve stimulation: Longitudinal follow-up patients treated for 5 years.
JF - Seizure
VL - 18
IS - 4
SP - 269-274
EP - 269-274
SN - 10591311
KW - vagus nerve stimulation
KW - efficacy
KW - long-term outcome
KW - comlications
N2 - We performed a retrospective, multicenter, open-label study to evaluate the efficacy Of vagus nerve stimulation (VNS) in all patients in the Czech Republic who have received this treatment for at least 5 years (n = 90). The mean last follow-up was 6.6 +/- 1.1 years (79 +/- 13 months). The median number of seizures among all patients decreased from 41.2 seizures/month in the prestimulation period to 14.9 seizures/month at 5 years follow-up visit. The mean percentage of seizure reduction was 55.9%. The responder rate in these patients is in concordance with the decrease of overall seizure frequency. At 1 year after beginning the stimulation, 44.4% of patients were responders; this percentage increased to 58.7% after 2 years. At the 5 years last follow-up 64.4% of patients were responders, 15.5% experienced >= 90% seizure reduction, and 5.5% were seizure-free. A separate analysis of patients younger than 16 years of age showed lower efficacy rates of VNS in comparison to the whole group. Complications and chronic adverse effects occurred in 13.3% of patients. VNS is an effective and safe method to refractory epilepsy in common clinical practice.
ER -
KUBA, Robert, Milan BRÁZDIL, Miroslav KALINA, Tomáš PROCHÁZKA, Jiří HOVORKA, Tomáš NEŽÁDAL, Jan HADAČ, Klára BROŽOVÁ, Věra SEBROŇOVÁ, Vladimír KOMÁREK, Petr MARUSIČ, Hana OŠLEJŠKOVÁ, Jana ZARUBOVA and Ivan REKTOR. Vagus nerve stimulation: Longitudinal follow-up patients treated for 5 years. \textit{Seizure}. 2009, vol.~18, No~4, p.~269-274. ISSN~1059-1311. Available from: https://dx.doi.org/10.1016/j.seizure.2008.10.012.
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