Immune response to the herpes simplex type 1 regulatory
proteins ICP8 and VP16 in infected persons

J 2000

Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons

SPATZ, M., HM. WOLF, Vojtěch THON, JM. GAMPFER, MM. EIBL et. al.

Základní údaje

Originální název

Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons

Název česky

Imunitní odpověď na regulační proteiny ICP8 and VP16 herpes simplex viru typu 1 u infikovaných osob

Autoři

SPATZ, M. (40 Rakousko), HM. WOLF (40 Rakousko), Vojtěch THON (203 Česká republika, garant), JM. GAMPFER (276 Německo) a MM. EIBL (40 Rakousko)

Vydání

JOURNAL OF MEDICAL VIROLOGY, 2000, 0146-6615

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.289

Kód RIV

RIV/00216224:14110/00:00035789

Organizační jednotka

Lékařská fakulta

UT WoS

000088492800005

Klíčová slova česky

herpes simplex virus

Klíčová slova anglicky

T CELL CLONES; PRIMARY GENITAL HERPES; NECROSIS FACTOR ALPHA; VIRUS TYPE 1; DENDRITIC CELLS; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; GENE EXPRESSION;

Štítky

ANTIBODY RESPONSE, antigen presentation, dendritic cells, GENE EXPRESSION, NECROSIS FACTOR ALPHA, PRIMARY GENITAL HERPES, T CELL CLONES, VIRUS TYPE 1

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:14, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

The specific immune responses directed against the viral single stranded (ss) DNA binding protein ICP8 and the transactivator of immediate early (IE) gene expression VP16 (alpha-trans inducing factor, Vmw65) in HSV type 1 seropositive humans were examined. The results described in this paper indicate that neither ICP8 nor VP16 were able to induce a recall response in lymphocytes of healthy HSV seropositive individuals without recurrent infection, although CD4+ T cells purified from these individuals responded to both viral proteins in vitro when monocyte derived dendritic cells were used as antigen presenting cells. A recall response, however, could be induced to both viral proteins in T cells of patients with recurrent HSV infections when blood monocytes were used. Moreover, ICP8- and VP16-specific antibodies could be detected in the serum of patients with recurrent HSV infections whereas, in contrast, these antibodies were virtually absent in healthy HSV seropositive individuals without recurrences. These data represent the first systematic study of the immunological properties of ICP8 in humans, indicating a significant difference in the response to the essential viral regulators ICP8 and VP16 in HSV-1 seropositive healthy individuals as opposed to patients with recurrent HSV-1 infections.

Česky

Imunitní odpověď na regulační proteiny ICP8 and VP16 herpes simplex viru typu 1 u infikovaných osob.

Citovat

SPATZ, M., HM. WOLF, Vojtěch THON, JM. GAMPFER a MM. EIBL. Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons. JOURNAL OF MEDICAL VIROLOGY. 2000, roč. 62, č. 1, s. 29-36. ISSN 0146-6615.

@article{837062,
   author = {Spatz, M. and Wolf, HM. and Thon, Vojtěch and Gampfer, JM. and Eibl, MM.},
   article_number = {1},
   keywords = {T CELL CLONES; PRIMARY GENITAL HERPES; NECROSIS FACTOR ALPHA; VIRUS TYPE 1; DENDRITIC CELLS; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; GENE EXPRESSION;},
   language = {eng},
   issn = {0146-6615},
   journal = {JOURNAL OF MEDICAL VIROLOGY},
   title = {Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons},
   volume = {62},
   year = {2000}
}

TY  - JOUR
ID  - 837062
AU  - Spatz, M. - Wolf, HM. - Thon, Vojtěch - Gampfer, JM. - Eibl, MM.
PY  - 2000
TI  - Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons
JF  - JOURNAL OF MEDICAL VIROLOGY
VL  - 62
IS  - 1
SP  - 29-36
EP  - 29-36
SN  - 01466615
KW  - T CELL CLONES
KW  - PRIMARY GENITAL HERPES
KW  - NECROSIS FACTOR ALPHA
KW  - VIRUS TYPE 1
KW  - DENDRITIC CELLS
KW  - ANTIBODY RESPONSE
KW  - ANTIGEN PRESENTATION
KW  - GENE EXPRESSION;
N2  - The specific immune responses directed against the viral single stranded (ss) DNA binding protein ICP8 and the transactivator of immediate early (IE) gene expression VP16 (alpha-trans inducing factor, Vmw65) in HSV type 1 seropositive humans were examined. The results described in this paper indicate that neither ICP8 nor VP16 were able to induce a recall response in lymphocytes of healthy HSV seropositive individuals without recurrent infection, although CD4+ T cells purified from these individuals responded to both viral proteins in vitro when monocyte derived dendritic cells were used as antigen presenting cells. A recall response, however, could be induced to both viral proteins in T cells of patients with recurrent HSV infections when blood monocytes were used. Moreover, ICP8- and VP16-specific antibodies could be detected in the serum of patients with recurrent HSV infections whereas, in contrast, these antibodies were virtually absent in healthy HSV seropositive individuals without recurrences. These data represent the first systematic study of the immunological properties of ICP8 in humans, indicating a significant difference in the response to the essential viral regulators ICP8 and VP16 in HSV-1 seropositive healthy individuals as opposed to patients with recurrent HSV-1 infections.
ER  -

SPATZ, M., HM. WOLF, Vojtěch THON, JM. GAMPFER a MM. EIBL. Immune response to the herpes simplex type 1 regulatory proteins ICP8 and VP16 in infected persons. \textit{JOURNAL OF MEDICAL VIROLOGY}. 2000, roč.~62, č.~1, s.~29-36. ISSN~0146-6615.

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