T cell activity and cytokine production in X-linked
agammaglobulinemia: Implications for vaccination strategies

J 1997

T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies

PLEBANI, A., MB. FISCHER, A. MEINI, M. DUSE, Vojtěch THON et. al.

Základní údaje

Originální název

T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies

Název česky

T buněčná aktivita a cytokinová produkce u X vázané agamaglobulinemie: důsledky pro vakcinační strategii

Autoři

PLEBANI, A. (380 Itálie), MB. FISCHER (40 Rakousko), A. MEINI (380 Itálie), M. DUSE (380 Itálie), Vojtěch THON (203 Česká republika, garant) a MM. EIBL (40 Rakousko)

Vydání

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1997, 1018-2438

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.721

Kód RIV

RIV/00216224:14110/97:00035798

Organizační jednotka

Lékařská fakulta

UT WoS

A1997XR99700014

Klíčová slova česky

XLA; vakcinace

Klíčová slova anglicky

X linked agammaglobulinemia; vaccine; cytokines; cell mediated immunity

Štítky

cell mediated immunity, cytokines, vaccine, X linked agammaglobulinemia

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:17, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

In the 5 X-linked agammaglobulinelnia (XLA) patients studied we show that memory T cells are present and that T lymphocytes proliferate normally to mitogens, monoclonal antibodies and, in particular, to recall antigens demonstrating normal in vivo T cell priming despite the absence of B cells. Furthermore, in vitro T cell activation in response to both T cell receptor-independent and T-cell receptor-dependent signals leads to a pattern of cytokine production characteristic of primed T cells and necessary for normal T cell function. These data are in good agreement with results obtained in gene-targeted mice and further support the concept that the absence of B cells does not impair induction of in vivo T cell memory and effector function which is generally considered to be of great importance in conferring protection against viral infections. Thus, while there is no risk of inducing infections in XLA patients by administering vaccines containing killed viruses or recombinant viral proteins, stimulation of T cell immunity by such vaccines may be of potential benefit particularly in the defense against infections with viruses such as the hepatitis B virus to which hypogammaglobulinemic patients are particularly exposed.

Česky

T buněčná aktivita a cytokinová produkce u X vázané agamaglobulinemie: důsledky pro vakcinační strategii.

Citovat

PLEBANI, A., MB. FISCHER, A. MEINI, M. DUSE, Vojtěch THON a MM. EIBL. T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1997, roč. 114, č. 1, s. 90-93. ISSN 1018-2438.

@article{837099,
   author = {Plebani, A. and Fischer, MB. and Meini, A. and Duse, M. and Thon, Vojtěch and Eibl, MM.},
   article_number = {1},
   keywords = {X linked agammaglobulinemia; vaccine; cytokines; cell mediated immunity},
   language = {eng},
   issn = {1018-2438},
   journal = {INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY},
   title = {T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies},
   volume = {114},
   year = {1997}
}

TY  - JOUR
ID  - 837099
AU  - Plebani, A. - Fischer, MB. - Meini, A. - Duse, M. - Thon, Vojtěch - Eibl, MM.
PY  - 1997
TI  - T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies
JF  - INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
VL  - 114
IS  - 1
SP  - 90-93
EP  - 90-93
SN  - 10182438
KW  - X linked agammaglobulinemia
KW  - vaccine
KW  - cytokines
KW  - cell mediated immunity
N2  - In the 5 X-linked agammaglobulinelnia (XLA) patients studied we show that memory T cells are present and that T lymphocytes proliferate normally to mitogens, monoclonal antibodies and, in particular, to recall antigens demonstrating normal in vivo T cell priming despite the absence of B cells. Furthermore, in vitro T cell activation in response to both T cell receptor-independent and T-cell receptor-dependent signals leads to a pattern of cytokine production characteristic of primed T cells and necessary for normal T cell function. These data are in good agreement with results obtained in gene-targeted mice and further support the concept that the absence of B cells does not impair induction of in vivo T cell memory and effector function which is generally considered to be of great importance in conferring protection against viral infections. Thus, while there is no risk of inducing infections in XLA patients by administering vaccines containing killed viruses or recombinant viral proteins, stimulation of T cell immunity by such vaccines may be of potential benefit particularly in the defense against infections with viruses such as the hepatitis B virus to which hypogammaglobulinemic patients are particularly exposed.
ER  -

PLEBANI, A., MB. FISCHER, A. MEINI, M. DUSE, Vojtěch THON a MM. EIBL. T cell activity and cytokine production in X-linked agammaglobulinemia: Implications for vaccination strategies. \textit{INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY}. 1997, roč.~114, č.~1, s.~90-93. ISSN~1018-2438.

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