FISCHER, MB., I. HAUBER, M. FODINGER, HM. WOLF, Vojtěch THON, P. DONATH, MM. EIBL and RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995, vol. 104, No 4, p. 537-540. ISSN 0022-202X. |
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@article{837108, author = {Fischer, MB. and Hauber, I. and Fodinger, M. and Wolf, HM. and Thon, Vojtěch and Donath, P. and Eibl, MM. and Knobler, RM,}, article_number = {4}, keywords = {RECEPTOR COMPLEX; LYMPHOCYTES T; ANTIGEN; SEQUENCE; SUBUNITS; T cell lymphoma}, language = {eng}, issn = {0022-202X}, journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY}, title = {DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA}, volume = {104}, year = {1995} }
TY - JOUR ID - 837108 AU - Fischer, MB. - Hauber, I. - Fodinger, M. - Wolf, HM. - Thon, Vojtěch - Donath, P. - Eibl, MM. - Knobler, RM, PY - 1995 TI - DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY VL - 104 IS - 4 SP - 537-540 EP - 537-540 SN - 0022202X KW - RECEPTOR COMPLEX KW - LYMPHOCYTES T KW - ANTIGEN KW - SEQUENCE KW - SUBUNITS KW - T cell lymphoma N2 - We report on a patient with cutaneous T-cell lymphoma (CTCL) of long-standing duration. Phenotypic analysis of his peripheral blood mononuclear cells revealed an increased CD4(+) T-helper subset and a decreased CD8(+) cytotoxic T-cell population. Eighty-three to ninety-three percent of the patient's CD4(+) T cells in the peripheral blood and 70% of the CD4(+) T cells in the lesional skin lacked surface expression of the TCR/CD3 complex and showed a clonal rearrangement pattern of the TCR gamma-chain gene (V11-J1/J2). The lack in TCR surface expression correlated with defective assembly of the TCR beta-chain. Although mRNA for the TCR constant region beta 1 was found in the patient's purified CD4(+)TCR(-)CD3(-) T cells, no intracytoplasmic TCR beta protein was detectable. In contrast, the patient's purified CD4(+)TCR(-)CD3(-) T cells not only expressed mRNA specific for the TCR alpha-chain and for all CD3 chains, but intracytoplasmic TCR alpha and CD3 epsilon proteins could also be found. The lack of TCR beta protein clearly explains the defective surface expression of the TCR/CD3 complex in the patient's malignant T cells. ER -
FISCHER, MB., I. HAUBER, M. FODINGER, HM. WOLF, Vojtěch THON, P. DONATH, MM. EIBL and RM, KNOBLER. DEFECTIVE TCR SURFACE EXPRESSION ASSOCIATED WITH IMPAIRED TCR BETA-CHAIN ASSEMBLY IN A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA. \textit{JOURNAL OF INVESTIGATIVE DERMATOLOGY}. 1995, vol.~104, No~4, p.~537-540. ISSN~0022-202X.
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