A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL
ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

J 1994

A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

FISCHER, MB., I. HAUBER, H. EGGENBAUER, Vojtěch THON, E. VOGEL et. al.

Základní údaje

Originální název

A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

Název česky

Porucha časné fáze TCR zprostředkované T buněčné aktivace u pacientů s běžnou variabilní imunodeficiencí

Autoři

FISCHER, MB. (40 Rakousko), I. HAUBER (276 Německo), H. EGGENBAUER (40 Rakousko), Vojtěch THON (203 Česká republika, garant), E. VOGEL (40 Rakousko), E. SCHAFFER (40 Rakousko), J. LOKAJ (203 Česká republika), J. LITZMAN (203 Česká republika), HM. WOLF (40 Rakousko) a JW. MANNHALTER (40 Rakousko)

Vydání

BLOOD, 1994, 0006-4971

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Rusko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/94:00035804

Organizační jednotka

Lékařská fakulta

UT WoS

A1994PX14600028

Klíčová slova česky

CVID; TCR; T lymfocyt

Klíčová slova anglicky

HUMAN B CELLS; PROLIFERATIVE RESPONSES; INTERFERON GAMMA; GENE EXPRESSION; INTERLEUKIN 2; HYPOGAMMAGLOBULINEMIA; IL 2; ANTIGEN; DIFFERENTIATION; ABNORMALITIES

Štítky

abnormalities, ANTIGEN, differentiation, GENE EXPRESSION, HUMAN B CELLS, hypogammaglobulinemia, IL 2, interferon gamma, interleukin 2, PROLIFERATIVE RESPONSES

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:32, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

Common variable immunodeficiency (CVID) is characterized by an impairment of specific antibody production and a decrease in all or selected Ig isotypes. Abnormalities at the level of the B cells, T cells, and antigen-presenting cells have been described. In the present study, we have focused our attention on T-cell activation in CVID. T cells from 15 of 24 patients failed to respond to recall antigens leg, tetanus toxoid, Escherichia coli), Of these 15 patients, 11 were studied in detail and showed significantly decreased T-cell proliferative responses and/or decreased interleukin-2 and interferon-gamma production on T-cell receptor-mediated stimulation with recall antigens and superantigens (staphylococcal enterotoxins [SEI); however, T-cell response to mitogens (anti-CD3 monoclonal antibody, phytohemagglutinin) was normal. The defect in interleukin-2 and interferon-gamma release on tetanus toroid stimulation could also be documented in purified CD4 T cells of the patients and was present in patients with high and normal CD8 counts alike. Furthermore, patients' T cells failed to mount a significant elevation in free intracellular calcium (Ca++ flux) in response to superantigen, whereas the response to phorbol myristate acetate and ionomycin, bypassing receptor-mediated signaling, was unimpaired. These results indicate a defect in the early phase of T-cell activation after triggering of the T-cell receptor in a significant subgroup of CVID patients.

Česky

Porucha časné fáze TCR zprostředkované T buněčné aktivace u pacientů s běžnou variabilní imunodeficiencí.

Citovat

FISCHER, MB., I. HAUBER, H. EGGENBAUER, Vojtěch THON, E. VOGEL, E. SCHAFFER, J. LOKAJ, J. LITZMAN, HM. WOLF a JW. MANNHALTER. A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. BLOOD. 1994, roč. 84, č. 12, s. 4234-4241, 7 s. ISSN 0006-4971.

@article{837110,
   author = {Fischer, MB. and Hauber, I. and Eggenbauer, H. and Thon, Vojtěch and Vogel, E. and Schaffer, E. and Lokaj, J. and Litzman, J. and Wolf, HM. and Mannhalter, JW.},
   article_number = {12},
   keywords = {HUMAN B CELLS; PROLIFERATIVE RESPONSES; INTERFERON GAMMA; GENE EXPRESSION; INTERLEUKIN 2; HYPOGAMMAGLOBULINEMIA; IL 2; ANTIGEN; DIFFERENTIATION; ABNORMALITIES},
   language = {eng},
   issn = {0006-4971},
   journal = {BLOOD},
   title = {A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY},
   volume = {84},
   year = {1994}
}

TY  - JOUR
ID  - 837110
AU  - Fischer, MB. - Hauber, I. - Eggenbauer, H. - Thon, Vojtěch - Vogel, E. - Schaffer, E. - Lokaj, J. - Litzman, J. - Wolf, HM. - Mannhalter, JW.
PY  - 1994
TI  - A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
JF  - BLOOD
VL  - 84
IS  - 12
SP  - 4234-4241
EP  - 4234-4241
SN  - 00064971
KW  - HUMAN B CELLS
KW  - PROLIFERATIVE RESPONSES
KW  - INTERFERON GAMMA
KW  - GENE EXPRESSION
KW  - INTERLEUKIN 2
KW  - HYPOGAMMAGLOBULINEMIA
KW  - IL 2
KW  - ANTIGEN
KW  - DIFFERENTIATION
KW  - ABNORMALITIES
N2  - Common variable immunodeficiency (CVID) is characterized by an impairment of specific antibody production and a decrease in all or selected Ig isotypes. Abnormalities at the level of the B cells, T cells, and antigen-presenting cells have been described. In the present study, we have focused our attention on T-cell activation in CVID. T cells from 15 of 24 patients failed to respond to recall antigens leg, tetanus toxoid, Escherichia coli), Of these 15 patients, 11 were studied in detail and showed significantly decreased T-cell proliferative responses and/or decreased interleukin-2 and interferon-gamma production on T-cell receptor-mediated stimulation with recall antigens and superantigens (staphylococcal enterotoxins [SEI); however, T-cell response to mitogens (anti-CD3 monoclonal antibody, phytohemagglutinin) was normal. The defect in interleukin-2 and interferon-gamma release on tetanus toroid stimulation could also be documented in purified CD4 T cells of the patients and was present in patients with high and normal CD8 counts alike. Furthermore, patients' T cells failed to mount a significant elevation in free intracellular calcium (Ca++ flux) in response to superantigen, whereas the response to phorbol myristate acetate and ionomycin, bypassing receptor-mediated signaling, was unimpaired. These results indicate a defect in the early phase of T-cell activation after triggering of the T-cell receptor in a significant subgroup of CVID patients.
ER  -

FISCHER, MB., I. HAUBER, H. EGGENBAUER, Vojtěch THON, E. VOGEL, E. SCHAFFER, J. LOKAJ, J. LITZMAN, HM. WOLF a JW. MANNHALTER. A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. \textit{BLOOD}. 1994, roč.~84, č.~12, s.~4234-4241, 7 s. ISSN~0006-4971.

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