THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT
CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS
WITH COMMON VARIABLE IMMUNODEFICIENCY

J 1994

THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

FISCHER, MB., HM. WOLF, H. EGGENBAUER, Vojtěch THON, E. VOGEL et. al.

Základní údaje

Originální název

THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

Název česky

Kostimulační signál CD28 je plně funkční, avšak nedokáže korigovat porušenou antigenní odpověď T lymfocytů u pacientů s běžnou variabilní imunodeficiencí

Autoři

FISCHER, MB. (40 Rakousko), HM. WOLF (40 Rakousko), H. EGGENBAUER (40 Rakousko), Vojtěch THON (203 Česká republika, garant), E. VOGEL (40 Rakousko), J. LOKAJ (203 Česká republika), J. LITZMAN (203 Česká republika), JW. MANNHALTER (40 Rakousko) a MM. EIBL (40 Rakousko)

Vydání

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1994, 0009-9104

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/94:00035805

Organizační jednotka

Lékařská fakulta

UT WoS

A1994MU82700003

Klíčová slova česky

CVID; CD28; TCR

Klíčová slova anglicky

COMMON VARIABLE IMMUNODEFICIENCY; ANTIBODY DEFICIENCY; EFFECT OF CD28 IN CVID; EARLY T CELL ACTIVATION DEFECT; IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS

Štítky

ANTIBODY DEFICIENCY, common variable immunodeficiency

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:32, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results. Erogenous rIL-2, another costimulus, augmented but did not correct the defective proliferation and lymphokine production in patients' antigen-driven peripheral blood T lymphocytes or in long-term cultured T cells. These findings indicate that the CD28 signalling pathway in these patients' T cells is unimpaired, and that costimulation via CD28 cannot correct the defect occurring in the course of TCR-mediated T cell activation.

Česky

Kostimulační signál CD28 je plně funkční, avšak nedokáže korigovat porušenou antigenní odpověď T lymfocytů u pacientů s běžnou variabilní imunodeficiencí.

Citovat

FISCHER, MB., HM. WOLF, H. EGGENBAUER, Vojtěch THON, E. VOGEL, J. LOKAJ, J. LITZMAN, JW. MANNHALTER a MM. EIBL. THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 1994, roč. 95, č. 2, s. 209-214. ISSN 0009-9104.

@article{837112,
   author = {Fischer, MB. and Wolf, HM. and Eggenbauer, H. and Thon, Vojtěch and Vogel, E. and Lokaj, J. and Litzman, J. and Mannhalter, JW. and Eibl, MM.},
   article_number = {2},
   keywords = {COMMON VARIABLE IMMUNODEFICIENCY; ANTIBODY DEFICIENCY; EFFECT OF CD28 IN CVID; EARLY T CELL ACTIVATION DEFECT; IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS},
   language = {eng},
   issn = {0009-9104},
   journal = {CLINICAL AND EXPERIMENTAL IMMUNOLOGY},
   title = {THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY},
   volume = {95},
   year = {1994}
}

TY  - JOUR
ID  - 837112
AU  - Fischer, MB. - Wolf, HM. - Eggenbauer, H. - Thon, Vojtěch - Vogel, E. - Lokaj, J. - Litzman, J. - Mannhalter, JW. - Eibl, MM.
PY  - 1994
TI  - THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
JF  - CLINICAL AND EXPERIMENTAL IMMUNOLOGY
VL  - 95
IS  - 2
SP  - 209-214
EP  - 209-214
SN  - 00099104
KW  - COMMON VARIABLE IMMUNODEFICIENCY
KW  - ANTIBODY DEFICIENCY
KW  - EFFECT OF CD28 IN CVID
KW  - EARLY T CELL ACTIVATION DEFECT
KW  - IMPAIRED RESPONSE TO RECALL ANTIGENS IN CVID T CELLS
N2  - A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cells to tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results. Erogenous rIL-2, another costimulus, augmented but did not correct the defective proliferation and lymphokine production in patients' antigen-driven peripheral blood T lymphocytes or in long-term cultured T cells. These findings indicate that the CD28 signalling pathway in these patients' T cells is unimpaired, and that costimulation via CD28 cannot correct the defect occurring in the course of TCR-mediated T cell activation.
ER  -

FISCHER, MB., HM. WOLF, H. EGGENBAUER, Vojtěch THON, E. VOGEL, J. LOKAJ, J. LITZMAN, JW. MANNHALTER a MM. EIBL. THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. \textit{CLINICAL AND EXPERIMENTAL IMMUNOLOGY}. 1994, roč.~95, č.~2, s.~209-214. ISSN~0009-9104.

Podrobný výpis o publikaci