2009
MicroRNA involvement in glioblastoma pathogenesis
NOVÁKOVÁ, Jana, Ondřej SLABÝ, Rostislav VYZULA a Jaroslav MICHÁLEKZákladní údaje
Originální název
MicroRNA involvement in glioblastoma pathogenesis
Název česky
Zapojení mikroRNA do patogeneze glioblastomu
Autoři
NOVÁKOVÁ, Jana (203 Česká republika), Ondřej SLABÝ (203 Česká republika, garant), Rostislav VYZULA (203 Česká republika) a Jaroslav MICHÁLEK (203 Česká republika)
Vydání
Biochemical and Biophysical Research Communications, San Diego (USA), Elsevier, 2009, 0006-291X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Řecko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.548
Kód RIV
RIV/00216224:14110/09:00035862
Organizační jednotka
Lékařská fakulta
UT WoS
000267868800001
Klíčová slova česky
mikroRNA; glioblastom; patogeneze; apoptoza; buněčný cyklus
Klíčová slova anglicky
MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 30. 9. 2010 15:41, prof. RNDr. Ondřej Slabý, Ph.D.
V originále
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
Česky
MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.
Návaznosti
| NS9875, projekt VaV |
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