| KAPLAN, Peter, Milena MATEJOVIČOVÁ, Paul HERIJGERS and Willem FLAMENG. Lack of the effect of superoxide dismutase and catalase on Na+,K+-ATPase activity in stunned rabbit hearts. Physiological Research. Czech Republic: Academy of Sciences of the Czech Rep., 2008, vol. 57, Suppl. 2, p. S61-S66, 5 pp. ISSN 0862-8408. |
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@article{838024,
author = {Kaplan, Peter and Matejovičová, Milena and Herijgers, Paul and Flameng, Willem},
article_location = {Czech Republic},
article_number = {Suppl. 2},
keywords = {ISOLATED RAT-HEART; REPERFUSION INJURY; MYOCARDIAL-ISCHEMIA; FREE-RADICALS; OXIDATIVE STRESS; ATPASE ACTIVITY; OXYGEN; ARRHYTHMIAS; MECHANISMS; PROTECTION},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Lack of the effect of superoxide dismutase and catalase on Na+,K+-ATPase activity in stunned rabbit hearts},
url = {http://www.biomed.cas.cz/physiolres/pdf/57%20Suppl%202/57_S61.pdf},
volume = {57},
year = {2008}
}
TY - JOUR
ID - 838024
AU - Kaplan, Peter - Matejovičová, Milena - Herijgers, Paul - Flameng, Willem
PY - 2008
TI - Lack of the effect of superoxide dismutase and catalase on Na+,K+-ATPase activity in stunned rabbit hearts
JF - Physiological Research
VL - 57
IS - Suppl. 2
SP - S61-S66
EP - S61-S66
PB - Academy of Sciences of the Czech Rep.
SN - 08628408
KW - ISOLATED RAT-HEART
KW - REPERFUSION INJURY
KW - MYOCARDIAL-ISCHEMIA
KW - FREE-RADICALS
KW - OXIDATIVE STRESS
KW - ATPASE ACTIVITY
KW - OXYGEN
KW - ARRHYTHMIAS
KW - MECHANISMS
KW - PROTECTION
UR - http://www.biomed.cas.cz/physiolres/pdf/57%20Suppl%202/57_S61.pdf
N2 - Reactive oxygen species (ROS) have been implicated in the mechanism of postischemic contractile dysfunction, known as myocardial stunning. In this study, we examined protective effects of antioxidant enzymes, superoxide dismutase (SOD) and catalase, against ischemia/reperfusion-induced cardiac dysfunction and inhibition of Na+,K+-ATPase Activity. Isolated Langendorff-perfused rabbit hearts were subjected to 15 min of global normothermic ischemia followed by 10 min reperfusion. The hearts treated with SOD plus catalase did not show significant recovery of left ventricular (LV) end diastolic pressure compared with untreated ischemic reperfused hearts. Treatment with antioxidants had no pretective effects on developed LV pressure or its maximal positive and negative first derivatives (+/- LVdP/dt). Myocardial stunning was accompanied by significant loss in sarcolemmal Na+,K+-ATPase activity and thiol group content. Inhibition of enzyme activity and oxidation of SH groups were not prevented by antioxidant enzymes. These results suggest that administration of SOD and catalase in perfusate do not protect significantly against cardiac dysfunction in stunned rabbit myocardium.
ER -
KAPLAN, Peter, Milena MATEJOVIČOVÁ, Paul HERIJGERS and Willem FLAMENG. Lack of the effect of superoxide dismutase and catalase on Na+,K+-ATPase activity in stunned rabbit hearts. \textit{Physiological Research}. Czech Republic: Academy of Sciences of the Czech Rep., 2008, vol.~57, Suppl. 2, p.~S61-S66, 5 pp. ISSN~0862-8408.
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