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@misc{838039, author = {Zhao, Lianyun and Reddy, Panduranga Adulla and Shih, NengandYang and Paruch, Kamil and Guzi, Timothy and Siddiqui, Arshad}, keywords = {imidazopyrazines; kinase; inhibitor}, language = {eng}, title = {Imidazopyrazines as protein kinase inhibitors}, year = {2007} }
TY - PAT ID - 838039 AU - Zhao, Lianyun - Reddy, Panduranga Adulla - Shih, Neng-Yang - Paruch, Kamil - Guzi, Timothy - Siddiqui, Arshad PY - 2007 TI - Imidazopyrazines as protein kinase inhibitors KW - imidazopyrazines KW - kinase KW - inhibitor N2 - The invention provides a class of imidazopyrazine compds. of formula I as inhibitors of protein and/or checkpoint kinases, methods of prepg. such compds., pharmaceutical compns. including one or more such compds., methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. Compds. of formula I wherein R is H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted (hetero)cycloalkyl, etc.; R1 is H, (un)substituted alkyl, (un)substituted (hetero)aryl(alkyl), (un)substituted cycloalkenyl, etc.; R2 and R3 are independently H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, etc.; X is a covalent bond, CONH and derivs., SO2NH and derivs., NHCONH and derivs., CO2, OCO, OCONH and derivs., etc.; R4 is (un)substituted alkyl, (un)substituted CO2-alkyl, (un)substituted heterocyclyl, (un)substituted aryl and amine; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity (some data given). ER -
ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI. \textit{Imidazopyrazines as protein kinase inhibitors}. 2007. Patent. Číslo: WO 2007/145921 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 5. 6. 2007. Datum přijetí: 21. 12. 2007.
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