Imidazopyrazines as protein kinase inhibitors

ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI. Imidazopyrazines as protein kinase inhibitors. 2007. Patent. Číslo: WO 2007/145921 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 5. 6. 2007. Datum přijetí: 21. 12. 2007.

Základní údaje

• Originální název: Imidazopyrazines as protein kinase inhibitors
• Název česky: Imidazopyrazines as protein kinase inhibitors
• Autoři: ZHAO, Lianyun, Panduranga Adulla REDDY, Neng-Yang SHIH, Kamil PARUCH, Timothy GUZI a Arshad SIDDIQUI.
• Vydání: Číslo: WO 2007/145921 A1, Vydavatel: World Intellectual Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough, 2007.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Patent
• Obor: 30200 3.2 Clinical medicine
• Stát vydavatele: Spojené státy
• Utajení: není předmětem státního či obchodního tajemství
• Organizační jednotka: Přírodovědecká fakulta
• Klíčová slova česky: imidazopyrazines; kinase; inhibitor
• Klíčová slova anglicky: imidazopyrazines; kinase; inhibitor
• Štítky: imidazopyrazines, inhibitor, Kinase

Anotace

The invention provides a class of imidazopyrazine compds. of formula I as inhibitors of protein and/or checkpoint kinases, methods of prepg. such compds., pharmaceutical compns. including one or more such compds., methods of prepg. pharmaceutical formulations including one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns. Compds. of formula I wherein R is H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted (hetero)cycloalkyl, etc.; R1 is H, (un)substituted alkyl, (un)substituted (hetero)aryl(alkyl), (un)substituted cycloalkenyl, etc.; R2 and R3 are independently H, halo, amino, (un)substituted alkyl, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, etc.; X is a covalent bond, CONH and derivs., SO2NH and derivs., NHCONH and derivs., CO2, OCO, OCONH and derivs., etc.; R4 is (un)substituted alkyl, (un)substituted CO2-alkyl, (un)substituted heterocyclyl, (un)substituted aryl and amine; and their pharmaceutically acceptable salts, solvates, esters and prodrugs thereof, are claimed. Example compd. II was prepd. by a multistep procedure (procedure given). All the invention compds. were evaluated for their protein kinase inhibitory activity (some data given).

Anotace česky

viz Anotace