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@misc{838049, author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Labroli, Marc and Keertikar, Kartik}, keywords = {pyrazolopyrimidines; inhibitor; cyclin dependent kinase}, language = {eng}, title = {Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}, year = {2007} }
TY - PAT ID - 838049 AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Labroli, Marc - Keertikar, Kartik PY - 2007 TI - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors KW - pyrazolopyrimidines KW - inhibitor KW - cyclin dependent kinase N2 - The title compds. [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I, alone or in combination with other therapeutic agent, is claimed. ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI a Kartik KEERTIKAR. \textit{Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}. 2007. Patent. Číslo: US 2007/0281951 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 20. 4. 2007. Datum přijetí: 6. 12. 2007.
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