Methods for inhibiting protein kinases

P 2007

Methods for inhibiting protein kinases

GUZI, Timothy, Kamil PARUCH, Michael DWYER, David PARRY, Lianyun ZHAO et. al.

Základní údaje

Originální název

Methods for inhibiting protein kinases

Název česky

Methods for inhibiting protein kinases

Autoři

GUZI, Timothy, Kamil PARUCH, Michael DWYER, David PARRY, Lianyun ZHAO, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY, Arshad SIDDIQUI a Praveen TADIKONDA

Vydání

Číslo: US 2007/0105864 A1, Vydavatel: United States Patent and Trademark Office, Místo vydání: USA, Název vlastníka: Schering-Plough, 2007

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

kinases; cancer; inhibitor

Klíčová slova anglicky

kinases; cancer; inhibitor

Štítky

cancer, inhibitor, kinases

Změněno: 25. 6. 2009 15:02, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compds. of formula I and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with protein kinases using such compds. Compds. of formula I wherein R is H, halo, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, (un)substituted arylalkyl, (un)substituted heterocyclyl, etc.; R1 is H, halo, and alkyl; R2 is alkyl, (un)substituted (hetero)aryl(alkyl), alkenyl, alkynyl, etc.; R3 is H, (un)substituted (hetero)aryl(alkyl), (un)substituted heterocyclyl(alkyl), (un)substituted (hetero)cycloalkyl, etc.; and their pharmaceutically acceptable salts, solvates, esters, and prodrugs thereof are claimed. Example compd. II was prepd. by amination of 3-(1-methylpyrazol-4-yl)-7-methylsulfonylimidazo[1,2-a]pyrazine with 3-(methylsulfonyl)aniline. All the invention compds. were evaluated for their protein kinase inhibitory activity (data given).

Česky

viz Anotace

Citovat

GUZI, Timothy, Kamil PARUCH, Michael DWYER, David PARRY, Lianyun ZHAO, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY, Arshad SIDDIQUI a Praveen TADIKONDA. Methods for inhibiting protein kinases. 2007. Patent. Číslo: US 2007/0105864 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 8. 11. 2006. Datum přijetí: 10. 5. 2007.

@misc{838056,
   author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Parry, David and Zhao, Lianyun and Curran, Patrick and Belanger, David and Hamann, Blake and Reddy, Panduranga and Siddiqui, Arshad and Tadikonda, Praveen},
   keywords = {kinases; cancer; inhibitor},
   language = {eng},
   title = {Methods for inhibiting protein kinases},
   year = {2007}
}

TY  - PAT
ID  - 838056
AU  - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Parry, David - Zhao, Lianyun - Curran, Patrick - Belanger, David - Hamann, Blake - Reddy, Panduranga - Siddiqui, Arshad - Tadikonda, Praveen
PY  - 2007
TI  - Methods for inhibiting protein kinases
KW  - kinases
KW  - cancer
KW  - inhibitor
N2  - The invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compds. of formula I and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with protein kinases using such compds. Compds. of formula I wherein R is H, halo, (un)substituted (hetero)aryl, (un)substituted cycloalkyl, (un)substituted arylalkyl, (un)substituted heterocyclyl, etc.; R1 is H, halo, and alkyl; R2 is alkyl, (un)substituted (hetero)aryl(alkyl), alkenyl, alkynyl, etc.; R3 is H, (un)substituted (hetero)aryl(alkyl), (un)substituted heterocyclyl(alkyl), (un)substituted (hetero)cycloalkyl, etc.; and their pharmaceutically acceptable salts, solvates, esters, and prodrugs thereof are claimed. Example compd. II was prepd. by amination of 3-(1-methylpyrazol-4-yl)-7-methylsulfonylimidazo[1,2-a]pyrazine with 3-(methylsulfonyl)aniline. All the invention compds. were evaluated for their protein kinase inhibitory activity (data given).
ER  -

GUZI, Timothy, Kamil PARUCH, Michael DWYER, David PARRY, Lianyun ZHAO, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY, Arshad SIDDIQUI a Praveen TADIKONDA. \textit{Methods for inhibiting protein kinases}. 2007. Patent. Číslo: US 2007/0105864 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 8. 11. 2006. Datum přijetí: 10. 5. 2007.

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