Pyrazolopyrimidines as protein kinase inhibitors

PARUCH, Kamil, Timothy GUZI and Michael DWYER. Pyrazolopyrimidines as protein kinase inhibitors. 2007.

Basic information

Original name

Pyrazolopyrimidines as protein kinase inhibitors

Name in Czech

Pyrazolopyrimidines as protein kinase inhibitors

Authors

PARUCH, Kamil, Timothy GUZI and Michael DWYER

Edition

Number: US 2007/0082902 A1, Publisher: United States Patent and Trademark Office, Place of publication: USA, Owner's name: Schering-Plough, 2007

---

Other information

Language

English

Type of outcome

Patent

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

pyrazolopyrimidine; protein kinase; inhibitor

Keywords in English

pyrazolopyrimidine; protein kinase; inhibitor

Tags

inhibitor, protein kinase, pyrazolopyrimidine

---

Abstract

V originále

The title compds. I [R2 = H, alkyl, cycloalkyl, etc.; R3 = haloalkyl, alkenyl, aryl, etc.; R4 = H, halo, (halo)alkyl, etc.; R5 = H, halo, (halo)alkyl, etc.], useful as inhibitors of protein and/or checkpoint kinases, were prepd. E.g., a multistep synthesis of I [R2, R4 = H; R3 = Ph; R5 = NH2], starting from di-Et malonimidate dichloride, was given. Compd. I [R2, R4 = H; R3 = Ph; R5 = NH2] showed IC50 of 0.08 .mu.M against CDK2. This invention also relates to pharmaceutical compns. including one or more compds. I alone or in combination with therapeutic agents, methods of prepg. pharmaceutical formulations including one or more compds. I, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the protein or checkpoint kinases using such compds. or pharmaceutical compns.

In Czech

viz Anotace