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@misc{838075,
author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Siddiqui, Arshad and Reddy, Panduranga and Belanger, David and Hamann, Blake and Curran, Patrick},
keywords = {pyrazolopyrimidine; cyclin dependent kinase; inhibitor},
language = {eng},
title = {Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors},
year = {2007}
}
TY - PAT
ID - 838075
AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Siddiqui, Arshad - Reddy, Panduranga - Belanger, David - Hamann, Blake - Curran, Patrick
PY - 2007
TI - Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
KW - pyrazolopyrimidine
KW - cyclin dependent kinase
KW - inhibitor
N2 - Title compds. I [R = (un)substituted heteroaryl; R2 = alkyl, alkynyl, CF3, aryl, etc.; R3 = H, halo, alkyl, heteroaryl, etc.; R4 = H, halo or alkyl], and their pharmaceutically acceptable salts, are prepd. and disclosed as inhibitors of cyclin dependent kinases (CDKs). Thus, e.g., II was prepd. by substitution of III (prepn. given) with 3-aminoazetidine. In in vitro kinase activity assays, select compds. of the invention demonstrated IC50 values ranging from 0.05 - 49 (.mu.M). Further disclosed are pharmaceutical compns. contg. one or more of I, methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns.
ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Arshad SIDDIQUI, Panduranga REDDY, David BELANGER, Blake HAMANN a Patrick CURRAN. \textit{Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors}. 2007. Patent. Číslo: US 2007/0072882 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 4. 10. 2006. Datum přijetí: 29. 3. 2007.
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