Detailed Information on Publication Record
2001
Autologní transplantace hematopoetických buněk z periferní krve a následná udržovací léčba INF alfa nebo INF alfa s dexamethasonem u pacientů s mnohočetným myelomem - výsledky randomizované studie 4W České myelomové skupiny
KREJČÍ, Marta, Roman HÁJEK, Vlastimil ŠČUDLA, Jaroslav BAČOVSKÝ, Karel INDRÁK et. al.Basic information
Original name
Autologní transplantace hematopoetických buněk z periferní krve a následná udržovací léčba INF alfa nebo INF alfa s dexamethasonem u pacientů s mnohočetným myelomem - výsledky randomizované studie 4W České myelomové skupiny
Name in Czech
Autologní transplantace hematopoetických buněk z periferní krve a následná udržovací léčba INF alfa nebo INF alfa s dexamethasonem u pacientů s mnohočetným myelomem - výsledky randomizované studie 4W České myelomové skupiny
Name (in English)
Autologous transplantation of peripheral hematopoietic cells and subsequent maintenance therapy with interferon alpha or interferon alpha and dexamethasone in patients with multiple myeloma-results from the 4W randomized clinical trial of the Czech Myel
Authors
KREJČÍ, Marta (203 Czech Republic, guarantor), Roman HÁJEK (203 Czech Republic), Vlastimil ŠČUDLA (203 Czech Republic), Jaroslav BAČOVSKÝ (203 Czech Republic), Karel INDRÁK (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Jiří MAYER (203 Czech Republic) and Jiří VORLÍČEK (203 Czech Republic)
Edition
Vnitřní lékařství, Praha, Česk lékařská společnost J. Ev. Purkyně, 2001, 0042-773X
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
Keywords (in Czech)
mnohočetný myelom; autologní transplantace; interferon alfa; dexametason
Keywords in English
multiple myeloma;autologous transplantation; interferon alpha; dexamethasone
Změněno: 23/6/2009 17:12, Mgr. Anna Potáčová, Ph.D.
V originále
V publikaci jsou uváděny výsledky randomizované studie 4W České myelomové skupiny.
In English
In the clinical 4W study patients with newly diagnosed multiple myeloma are included where the state of the disease calls for treatment, while high dose chemotherapy is not contraindicated. Treatment according to protocol 4W comprises induction chemotherapy VAD, mobilization of haematopoietic cells (cyclophosphamide 5 g/m2). This is followed by autologous transplantation (as a conditioning regime melfalan 200 mg/m2 is administered). The patients are randomized into two groups, the first one is given interferon alpha as maintenance treatment, in the second group alternates cyclically interferon alpha and dexamethasone treatment. So far between 1996 and Aug. 31 2000 in the 4W clinical study 167 patients were included. 113 patients after transplantation were evaluated incl. 13 (12%) who achieved complete remission of the disease (absence of paraprotein, negative immunofixation), 63 patients (56%) with remission of the disease (decline of paraprotein, by more than 75%). Another 24 patients (21%) achieved partial remission (decline of paraprotein by more than 50% but less than 75%). The peritransplantation mortality is 2.67%. So far there is no significant difference between the two groups on maintenance treatment as regards the mean period before a relapse of the disease (p = 0.567). The median of the mean survival was not reached so far. The authors describe the results of the internal analysis of data incl. statistical processing.