Haematopoetic stem cell transplantation in children in eastern
Europenean countries 185 - 2004: development, recent activity
and role of the EBMT/ESH Outreach Programe

J 2008

Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe

WACHOWIAK, J.; M. LABOPIN; M. MIANO; A. CHYBICKA; J. STARÝ et. al.

Basic information

Original name

Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe

Name in Czech

Transplantace kostní dřeně u dětí v letech 1985 2004 v centrech evropských zemí.

Authors

WACHOWIAK, J. (826 United Kingdom of Great Britain and Northern Ireland); M. LABOPIN (826 United Kingdom of Great Britain and Northern Ireland); M. MIANO (826 United Kingdom of Great Britain and Northern Ireland); A. CHYBICKA (203 Czech Republic); J. STARÝ (203 Czech Republic); Jaroslav ŠTĚRBA (203 Czech Republic, guarantor); T. MASSZI (826 United Kingdom of Great Britain and Northern Ireland); B. LABAR (826 United Kingdom of Great Britain and Northern Ireland); A. MASCHAN (826 United Kingdom of Great Britain and Northern Ireland); J.R. KOWALCZYK (826 United Kingdom of Great Britain and Northern Ireland); A. LANGE (826 United Kingdom of Great Britain and Northern Ireland); J. HOLOWIECKI (826 United Kingdom of Great Britain and Northern Ireland); N. KALMAN (826 United Kingdom of Great Britain and Northern Ireland); B.V. AFANASSIEV (826 United Kingdom of Great Britain and Northern Ireland) and G. DINI (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Bone Marrow Transplant, GB, London, NATURE PUBLISHING GROUP, 2008, 0268-3369

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 3.400

RIV identification code

RIV/00216224:14110/08:00028312

Organization unit

Faculty of Medicine

UT WoS

000256660100025

Keywords in English

HSCT Children Central and eastern European Countires

Abstract

ORIG CZ

In the original language

The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.

In Czech

Populace dětí v 19 zemích východní Evropy je cca 80 milionů. Práce popisuje celkem 2342 provedených transplantací kostní dřeně u dětí v letech 1985 2004 v celkem 24 centrech 19 zemí.

Links

1A8709, research and development project

Name: Rozlišení a molekulární analýza aloreaktivních a nádorově-specifických T lymfocytů in vitro

Investor: Ministry of Health of the CR

Cite

WACHOWIAK, J.; M. LABOPIN; M. MIANO; A. CHYBICKA; J. STARÝ; Jaroslav ŠTĚRBA; T. MASSZI; B. LABAR; A. MASCHAN; J.R. KOWALCZYK; A. LANGE; J. HOLOWIECKI; N. KALMAN; B.V. AFANASSIEV and G. DINI. Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe. Bone Marrow Transplant. GB, London: NATURE PUBLISHING GROUP, 2008, vol. 41, No 2, p. 112-117, 5 pp. ISSN 0268-3369.

@article{838235,
   author = {Wachowiak, J. and Labopin, M. and Miano, M. and Chybicka, A. and Starý, J. and Štěrba, Jaroslav and Masszi, T. and Labar, B. and Maschan, A. and Kowalczyk, J.R. and Lange, A. and Holowiecki, J. and Kalman, N. and Afanassiev, B.V. and Dini, G.},
   article_location = {GB, London},
   article_number = {2},
   keywords = {HSCT Children Central and eastern European Countires},
   language = {eng},
   issn = {0268-3369},
   journal = {Bone Marrow Transplant},
   title = {Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe},
   volume = {41},
   year = {2008}
}

TY  - JOUR
ID  - 838235
AU  - Wachowiak, J. - Labopin, M. - Miano, M. - Chybicka, A. - Starý, J. - Štěrba, Jaroslav - Masszi, T. - Labar, B. - Maschan, A. - Kowalczyk, J.R. - Lange, A. - Holowiecki, J. - Kalman, N. - Afanassiev, B.V. - Dini, G.
PY  - 2008
TI  - Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe
JF  - Bone Marrow Transplant
VL  - 41
IS  - 2
SP  - 112-117
EP  - 112-117
PB  - NATURE PUBLISHING GROUP
SN  - 02683369
KW  - HSCT Children Central and eastern European Countires
N2  - The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) in children increased from 1 in 1985 to 24 in 2004 and the yearly number of paediatric HSCTs rose from 1 in 1985 to 291 in 2004. Altogether, 2342 transplants were reported to the EBMT Registry during this time (Poland 953, Czech Republic 501, Hungary 269, Russia 217, Croatia 129, Slovakia 71, Bulgaria 45, Serbia and Montenegro 36, Slovenia 35, Belarus 33, Estonia 26, Lithuania 19 and Romania 8). Out of the 2342 transplants, 1487 (63.5%) transplants were performed in paediatric centres, 453 (19.3%) in centres for adults and 402 (17.2%) in combined centres. The number of children who underwent autologous HSCT (auto-HSCT) was 1053 (45%), whereas 1289 (55%) underwent allogeneic HSCT (allo-HSCT). Peripheral blood (PB) was the source of HSC in 751 (71.3%) out of 1053 auto-transplants, BM in 246 (23.4%) and PB+BM in 52 (4.9%) (missing data in 4, that is, 0.4%). Among the 1289 allo-transplants, BM was the source of HSC in 827 (64.3%), PB in 416 (32.3%), CB in 23 (1.8%) and BM+PB in 14 (1.1%) (missing data in 9, that is, 0.7%). Among them, 728 (57.4%) obtained HSC from MSD, 322 (25.4%) from UD, 195 (15.4%) from MMFD, 14 (1.1%) from CB family donor and 9 (0.7%) from CB unrelated donor (missing data in 21, that is, 1.6%). The number of children who underwent allo-HSCT for malignant diseases was 945 (73.4%), including ALL 376 (29.2%), AML 234 (18.2%), CML 177 (13.8%), MDS 97 (7.5%), NHL 35 (2.7%) and other malignancy 31 (2.4%), while 339 (26.9%) for non-malignant disorders, including SAA 202 (15.7%), immunodeficiencies 61 (4.7%), inborn errors of metabolism 40 (3.1%), Fanconi anaemia 19 (1.5%) and others 17 (1.3%). Out of 1053 recipients of auto-HSCT, 168 (16%) were transplanted for neuroblastoma, 129 (12.2%) for NHL, 124 (11.7%) for AML, 114 (10.8%) for ALL, 109 (10.4%) for Hodgkin's disease, 62 (5.9%) for Ewing's sarcoma, 16 (1.5%) for CNS tumour, 15 (1.4%) for Wilms tumour and 316 (30%) for other tumours. In 2001, the EBMT in collaboration with the European School of Haematology (ESH) developed the Outreach Programme, that is a programme supporting emerging HSCT projects and transplant centres in countries with limited resources and/or experience.
ER  -

WACHOWIAK, J.; M. LABOPIN; M. MIANO; A. CHYBICKA; J. STARÝ; Jaroslav ŠTĚRBA; T. MASSZI; B. LABAR; A. MASCHAN; J.R. KOWALCZYK; A. LANGE; J. HOLOWIECKI; N. KALMAN; B.V. AFANASSIEV and G. DINI. Haematopoetic stem cell transplantation in children in eastern Europenean countries 185 - 2004: development, recent activity and role of the EBMT/ESH Outreach Programe. \textit{Bone Marrow Transplant}. GB, London: NATURE PUBLISHING GROUP, 2008, vol.~41, No~2, p.~112-117, 5 pp. ISSN~0268-3369.

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