Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of
Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and
2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl
Derivatives of Imidazo[1,2-a]pyridines, and
Imidazo[1,5-a]pyrazines Compounds

P 2007

Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds

MALLAMS, Alan, Vincent MADISON a Kamil PARUCH

Základní údaje

Originální název

Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds

Název česky

Autoři

MALLAMS, Alan, Vincent MADISON a Kamil PARUCH

Vydání

Číslo: WO 2007/032936 A2, Vydavatel: World Intellectula Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough, 2007

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

10401 Organic chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

cyclin dependent kinase; inhibitor

Klíčová slova anglicky

cyclin dependent kinase; inhibitor

Štítky

Cyclin dependent kinase, inhibitor

Změněno: 25. 6. 2009 08:30, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity.

Česky

viz Anotace

Citovat

MALLAMS, Alan, Vincent MADISON a Kamil PARUCH. Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds. 2007. Patent. Číslo: WO 2007/032936 A2. Vydavatel: World Intellectula Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 31. 10. 2006. Datum přijetí: 22. 3. 2007.

@misc{838344,
   author = {Mallams, Alan and Madison, Vincent and Paruch, Kamil},
   keywords = {cyclin dependent kinase; inhibitor},
   language = {eng},
   title = {Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds},
   year = {2007}
}

TY  - PAT
ID  - 838344
AU  - Mallams, Alan - Madison, Vincent - Paruch, Kamil
PY  - 2007
TI  - Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds
KW  - cyclin dependent kinase
KW  - inhibitor
N2  - The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity.
ER  -

MALLAMS, Alan, Vincent MADISON a Kamil PARUCH. \textit{Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds}. 2007. Patent. Číslo: WO 2007/032936 A2. Vydavatel: World Intellectula Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 31. 10. 2006. Datum přijetí: 22. 3. 2007.

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