Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR. Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors. 2006.

Basic information

Original name

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Name in Czech

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Authors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Marc LABROLI and Kartik KEERTIKAR

Edition

Number: US 2006128725 A1, Publisher: US Patent Office, Place of publication: USA, Owner's name: Schering-Plough, 2006

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Other information

Language

English

Type of outcome

Patent

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords (in Czech)

cancer; pyrazolopyrimidines; cyclin dependent kinase; inhibitor

Keywords in English

cancer; pyrazolopyrimidines; cyclin dependent kinase; inhibitor

Tags

cancer, Cyclin dependent kinase, inhibitor, pyrazolopyrimidines

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Abstract

V originále

The title compds. are substituted pyrazolo[1,5-a]pyrimidines [I; R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.

In Czech

viz Anotace