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@misc{838349,
author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Zhao, Lianyun and Curran, Patrick and Belanger, David and Hamann, Blake and Reddy, Panduranga and Siddiqui, Arshad},
keywords = {imidazopyrazine; cyclin dependent kinase; inhibitor},
language = {eng},
title = {Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors},
year = {2006}
}
TY - PAT
ID - 838349
AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Zhao, Lianyun - Curran, Patrick - Belanger, David - Hamann, Blake - Reddy, Panduranga - Siddiqui, Arshad
PY - 2006
TI - Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors
KW - imidazopyrazine
KW - cyclin dependent kinase
KW - inhibitor
N2 - In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. of formula I [R = H, halo, (un)substituted-aryl, -heteroaryl, -cycloalkyl, etc.; R1 = H, halo or alkyl; R2 = halo, (un)substituted-alkyl, -aryl, -arylalkyl, etc.; R3 = H, (un)substituted-aryl, -heteroaryl, -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 8-chloro-3-methylimidazo[1,2-a]pyrazine with 4-(aminomethyl)pyridine. I possessed excellent CDK inhibitory properties, e.g., II demonstrated an IC50 value of 22.5 .mu.M.
ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Lianyun ZHAO, Patrick CURRAN, David BELANGER, Blake HAMANN, Panduranga REDDY a Arshad SIDDIQUI. \textit{Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors}. 2006. Patent. Číslo: US 2006106023 A1. Vydavatel: United States Patent and Trademark Office. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 10. 11. 2005. Datum přijetí: 18. 5. 2006.
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