Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors

P 2004

Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors

DWYER, Michael, Timothy GUZI, Kamil PARUCH, Ronald DOLL, Kartik KEERTIKAR et. al.

Základní údaje

Originální název

Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors

Název česky

Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors

Autoři

DWYER, Michael (840 Spojené státy), Timothy GUZI (840 Spojené státy), Kamil PARUCH (203 Česká republika, garant), Ronald DOLL (840 Spojené státy), Kartik KEERTIKAR (840 Spojené státy) a Viyyoor GIRIJAVALLABHAN (840 Spojené státy)

Vydání

Číslo: WO 2004/026872 A1, Vydavatel: World Intellectual Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough, 2004

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/04:00035989

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Klíčová slova anglicky

cyclin dependent kinase; inhibitor; pyrazolopyrimidine

Štítky

Cyclin dependent kinase, inhibitor, pyrazolopyrimidine

Změněno: 25. 6. 2009 09:52, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compds. I [R = (un)substiuted-alkyl, -aryl, -heteroaryl, -heteroarylalkyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, -aryl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, -aryl, -heteroaryl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 7-amino-5-phenylpyrazolo[1,5-a]pyridine (prepn. given) with 3-formylpyridine. I possessed excellent CDK inhibitory properties as demonstrated by the IC50 value for III of 0.078 .mu.M in inhibition of CDK2.

Česky

viz Anotace

Citovat

DWYER, Michael, Timothy GUZI, Kamil PARUCH, Ronald DOLL, Kartik KEERTIKAR a Viyyoor GIRIJAVALLABHAN. Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors. 2004. Patent. Číslo: WO 2004/026872 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 17. 9. 2003. Datum přijetí: 1. 4. 2004.

@misc{838384,
   author = {Dwyer, Michael and Guzi, Timothy and Paruch, Kamil and Doll, Ronald and Keertikar, Kartik and Girijavallabhan, Viyyoor},
   keywords = {cyclin dependent kinase; inhibitor; pyrazolopyrimidine},
   language = {eng},
   title = {Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors},
   year = {2004}
}

TY  - PAT
ID  - 838384
AU  - Dwyer, Michael - Guzi, Timothy - Paruch, Kamil - Doll, Ronald - Keertikar, Kartik - Girijavallabhan, Viyyoor
PY  - 2004
TI  - Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors
KW  - cyclin dependent kinase
KW  - inhibitor
KW  - pyrazolopyrimidine
N2  - In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compds. I [R = (un)substiuted-alkyl, -aryl, -heteroaryl, -heteroarylalkyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, -aryl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, -aryl, -heteroaryl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 7-amino-5-phenylpyrazolo[1,5-a]pyridine (prepn. given) with 3-formylpyridine. I possessed excellent CDK inhibitory properties as demonstrated by the IC50 value for III of 0.078 .mu.M in inhibition of CDK2.
ER  -

DWYER, Michael, Timothy GUZI, Kamil PARUCH, Ronald DOLL, Kartik KEERTIKAR a Viyyoor GIRIJAVALLABHAN. \textit{Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors}. 2004. Patent. Číslo: WO 2004/026872 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 17. 9. 2003. Datum přijetí: 1. 4. 2004.

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