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@misc{838399,
author = {Paruch, Kamil and Guzi, Timothy and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor},
keywords = {cyclin dependent kinase; imidazopyrazine; inhibitor},
language = {eng},
title = {Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors},
year = {2004}
}
TY - PAT
ID - 838399
AU - Paruch, Kamil - Guzi, Timothy - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor
PY - 2004
TI - Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors
KW - cyclin dependent kinase
KW - imidazopyrazine
KW - inhibitor
N2 - In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. I [R = CF3, (un)substituted-alkyl, -heteroaryl, -heteroarylalkyl, -cycloalkyl, -heterocyclyl, etc.; R1 = H, halo or alkyl; R2 = H, halo, CN, cycloalkyl, heterocyclyl, alkynyl and CF3; R3 = aryl (with exception of Ph), (un)subsituted-heteroaryl (with exception of furyl), -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by substitution of 8-chloro-6-methylimidzol[1,2-a]pyrazine with 3-(aminomethyl)pyridine. Methods for performing assays with I are described (no data).
ER -
PARUCH, Kamil, Timothy GUZI, Michael DWYER, Ronald DOLL a Viyyoor GIRIJAVALLABHAN. \textit{Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors}. 2004. Patent. Číslo: WO 2004/026310 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough. Datum registrace: 19. 9. 2003. Datum přijetí: 1. 4. 2004.
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