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@misc{838517,
author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor and Alvarez, Carmen and Chan, TinandYau and Knutson, Chad and Madison, Vincent and Fischmann, Thierry and Dillard, Lawrence and Tran, Vinh and He, Zhen and James, Ray and Park, Haengsoon},
keywords = {cyclin dependent kinase; inhibitor; pyrazolopyrimidine},
language = {eng},
title = {Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors},
year = {2004}
}
TY - PAT
ID - 838517
AU - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor - Alvarez, Carmen - Chan, Tin-Yau - Knutson, Chad - Madison, Vincent - Fischmann, Thierry - Dillard, Lawrence - Tran, Vinh - He, Zhen - James, Ray - Park, Haengsoon
PY - 2004
TI - Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
KW - cyclin dependent kinase
KW - inhibitor
KW - pyrazolopyrimidine
N2 - In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compds. I [R = (un)substituted aryl; R2 = halo, CN, (un)substituted alkyl, etc.; R3 = H, halo, (un)substituted-alkyl, -alkynyl, -aryl, etc.; R4 = H, halo or alkyl] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by substitution of 3-bromo-7-chloro-5-(2-chlorophenyl)-pyrazolo[1,5-a]pyrimidine (prepn. given) with aniline. I exhibit excellent CDK inhibitory properties as demonstrated by II which possessed a IC50 value of 0.51 uM in kinase activity assays.
ER -
GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN, Carmen ALVAREZ, Tin-Yau CHAN, Chad KNUTSON, Vincent MADISON, Thierry FISCHMANN, Lawrence DILLARD, Vinh TRAN, Zhen HE, Ray JAMES a Haengsoon PARK. \textit{Novel Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors}. 2004. Patent. Číslo: WO 2004/026229 A2. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough; Pharmacopeia. Datum registrace: 3. 9. 2003. Datum přijetí: 1. 4. 2004.
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