CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS
| PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra, Klaus GRASSER and Jiří FAJKUS. CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS. In Telomere and Telomeres. 2009. |
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| Basic information | |
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| Original name | CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS |
| Name in Czech | Chromatin associovaný protein HMGB1 je zapojen do regulace délky rostlinných telomer |
| Authors | PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra (203 Czech Republic), Klaus GRASSER (208 Denmark) and Jiří FAJKUS (203 Czech Republic, guarantor). |
| Edition | Telomere and Telomeres, 2009. |
| Other information | |
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| Original language | English |
| Type of outcome | Conference abstract |
| Field of Study | Genetics and molecular biology |
| Country of publisher | United States of America |
| Confidentiality degree | is not subject to a state or trade secret |
| RIV identification code | RIV/00216224:14310/09:00029389 |
| Organization unit | Faculty of Science |
| Keywords (in Czech) | Telomery; HMGB1; rostliny |
| Keywords in English | telomeres; HMGB1; plant |
| Tags | HMGB1, plant, telomere |
| Changed by | Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 9/4/2010 12:40. |
| Abstract |
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| High Mobility Group (HMG) proteins type B bind local DNA structures, promote DNA bending and interact with factors of the transcription, repair and recombination machineries. Arabidopsis thaliana genome encodes 7 HMGB proteins which differ in structure, expression pattern and DNA-binding properties. We observe that HMGB1 takes part in telomere maintenance. Plants lacking HMGB1 display telomere shortening and, consistently, overexpression of HMGB1 leads to telomere elongation. |
| Abstract (in Czech) |
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| High Mobility Group (HMG) proteiny typu B se váží na lokální DNA struktury, podporují ohyb DNA a interagují s proteiny zahrnutými do transkripční, reparační či rekombinační dráhy. Genom A. thaliana kóduje 7HMGB proteinů, které se liší ve struktuře, expresiním vzorci a vazbě na DNA. V naší práci jsme pozorovali, že HMGB1 protein se podílí na údržbě telomerických konců. Rosliny postrádající HMGB1 protein vykazují zkracování telomer; overexprese HMGB1 vede k prodlužování telomer. |
| Links | |
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| GA204/08/1530, research and development project | Name: Objasnění úlohy proteinu HMGB1 v udržování genomové stability |
| Investor: Czech Science Foundation, Understanding of HMGB1 protein involvement in maintaining genome stability | |
| GP521/08/P452, research and development project | Name: Charakterizace a funkční diverzita proteinů rodiny SMH, která je specifická pro rostliny |
| Investor: Czech Science Foundation, Characterisation of functional diversity of the plant-specific SMH family of proteins | |
| LC06004, research and development project | Name: Integrovaný výzkum rostlinného genomu |
| MSM0021622415, plan (intention) | Name: Molekulární podstata buněčných a tkáňových regulací |
| Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations | |
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