EVSIKOV, A.V., J.H. GRABER, J.M. BROCKMAN, Aleš HAMPL, A.E. HOLBROOK, P. SINGH, J.J. EPPIG, D. SOLTER a B.B. KNOWLES. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. GENES & DEVELOPMENT. 2006, roč. 20, č. 19, 2713-2727. ISSN 0890-9369. |
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@article{839397, author = {Evsikov, A.V. and Graber, J.H. and Brockman, J.M. and Hampl, Aleš and Holbrook, A.E. and Singh, P. and Eppig, J.J. and Solter, D. and Knowles, B.B.}, article_number = {19}, keywords = {eukaryotic initiation factor-4E; gene expression profiling; maternal effect gene; mRNA stability; multigene family; reproductive isolation; retroelements}, language = {eng}, issn = {0890-9369}, journal = {GENES & DEVELOPMENT}, title = {Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.}, volume = {20}, year = {2006} }
TY - JOUR ID - 839397 AU - Evsikov, A.V. - Graber, J.H. - Brockman, J.M. - Hampl, Aleš - Holbrook, A.E. - Singh, P. - Eppig, J.J. - Solter, D. - Knowles, B.B. PY - 2006 TI - Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. JF - GENES & DEVELOPMENT VL - 20 IS - 19 SN - 08909369 KW - eukaryotic initiation factor-4E KW - gene expression profiling KW - maternal effect gene KW - mRNA stability KW - multigene family KW - reproductive isolation KW - retroelements N2 - Fully grown oocytes (FGOs) contain all the necessary transcripts to activate molecular pathways underlying the oocyte-to-embryo transition (OET). To elucidate this critical period of development, an extensive survey of the FGO transcriptome was performed by analyzing 19,000 expressed sequence tags of the Mus musculus FGO cDNA library. A large proportion of identified genes belongs to several gene families with oocyte-restricted expression, a likely result of lineage-specific genomic duplications. Comparison of the FGO and two-cell embryo transcriptomes demarcated the processes important for oogenesis from those involved in OET and identified novel motifs in maternal mRNAs associated with transcript stability. These results implicate conserved pathways underlying transition from oogenesis to initiation of development and illustrate how genes acquire and lose reproductive functions during evolution. ER -
EVSIKOV, A.V., J.H. GRABER, J.M. BROCKMAN, Aleš HAMPL, A.E. HOLBROOK, P. SINGH, J.J. EPPIG, D. SOLTER a B.B. KNOWLES. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. \textit{GENES \&{} DEVELOPMENT}. 2006, roč.~20, č.~19, 2713-2727. ISSN~0890-9369.
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