Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding ...
BRŮNOVÁ, Lenka, Eva DEJMKOVÁ and Michaela WIMMEROVÁ. Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding properties. In Cukrblik 2009, Current Chemistry and Biochemistry of Carbohydrates. 2009. ISBN 978-80-210-4831-7. |
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Basic information | |
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Original name | Construction of mutant lectins from Chromobacterium violaceum and study of changes in their binding properties |
Name in Czech | Příprava mutantních lektinů z Chromobacterium violaceum a studium změn vazebných vlastností |
Authors | BRŮNOVÁ, Lenka (203 Czech Republic), Eva DEJMKOVÁ (203 Czech Republic, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution). |
Edition | Cukrblik 2009, Current Chemistry and Biochemistry of Carbohydrates, 2009. |
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Original language | English |
Type of outcome | Conference abstract |
Field of Study | 10600 1.6 Biological sciences |
Country of publisher | Czech Republic |
Confidentiality degree | is not subject to a state or trade secret |
RIV identification code | RIV/00216224:14310/09:00042640 |
Organization unit | Faculty of Science |
ISBN | 978-80-210-4831-7 |
Keywords in English | Lectins; Chromobacterium violaceum; changes of binding properties |
Tags | changes of binding properties, Chromobacterium violaceum, Lectins |
Changed by | Changed by: Mgr. Eva Dubská, učo 77638. Changed: 5/1/2011 18:46. |
Abstract |
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The aim of this work is in vitro creation of mutant lectins from oportunistic human pathogen Chromobacterium vioalceum. Substitution of amino acids in the lectin structure should lead to changes of lectin sugar specificity. Mutation were focused on the "specificity binding loop" in the position 22-23-24 and in other position 97. The work is going to be followed by structural and functional analysis. |
Abstract (in Czech) |
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Cílem této práce je připravit mutantní lektiny z patogenního organismu Chromobacterium violaceum. Záměna amino kyselin ve struktuře lektinu může vést ke změnám vazebných vlastností lektinu. Mutace byly zaměřeny do místa vazebné specifity v pozici 22-23-24 a do místa v pozici 97. Vazebné vlasnosti mutantních lektinů budou následně charakterizovány strukturně funkčními studiemi. |
Links | |
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LC06030, research and development project | Name: Biomolekulární centrum |
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre | |
MSM0021622413, plan (intention) | Name: Proteiny v metabolismu a při interakci organismů s prostředím |
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment |
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