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@article{840980, author = {Damborský, Jiří and Brezovský, Jan}, article_location = {England}, article_number = {13}, keywords = {protein; engineering; biocatalysts}, language = {eng}, issn = {1367-5931}, journal = {CURRENT OPINION IN BIOLOGICAL CHEMISTRY}, title = {Computational Tools for Designing and Engineering Biocatalysts.}, url = {http://loschmidt.chemi.muni.cz/peg/pdf/cochbi09.pdf}, volume = {1}, year = {2009} }
TY - JOUR ID - 840980 AU - Damborský, Jiří - Brezovský, Jan PY - 2009 TI - Computational Tools for Designing and Engineering Biocatalysts. JF - CURRENT OPINION IN BIOLOGICAL CHEMISTRY VL - 1 IS - 13 SP - 26-34 EP - 26-34 SN - 13675931 KW - protein KW - engineering KW - biocatalysts UR - http://loschmidt.chemi.muni.cz/peg/pdf/cochbi09.pdf N2 - Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs. ER -
DAMBORSKÝ, Jiří a Jan BREZOVSKÝ. Computational Tools for Designing and Engineering Biocatalysts. \textit{CURRENT OPINION IN BIOLOGICAL CHEMISTRY}. England, 2009, roč.~1, č.~13, s.~26-34. ISSN~1367-5931.
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