BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Lenka SÁBLÍKOVÁ, Lenka SLOVÁČKOVÁ, Martin FOREJT, Zlata PISKÁČKOVÁ, Lenka KUČEROVÁ, Kateřina HECZKOVÁ, Zuzana DERFLEROVÁ BRÁZDOVÁ and Anna VAŠKŮ. Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech 4 adult population. Genes and Nutrition. New Century Health Publishers, 2009, vol. 2009, No 4, p. 207-213. ISSN 1555-8932.
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Basic information
Original name Effect of ID ACE gene polymorphism on dietary composition and obesity-related anthropometric parameters in the Czech 4 adult population
Name in Czech Efekt inzerčně-delečního polymorfismu v genu pro angiotensin-konvertující enzym na složení stravy a antropometrické parametry související s obezitou u české populace
Authors BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Petr BIENERT (203 Czech Republic), Lenka SÁBLÍKOVÁ (203 Czech Republic), Lenka SLOVÁČKOVÁ (203 Czech Republic), Martin FOREJT (203 Czech Republic), Zlata PISKÁČKOVÁ (203 Czech Republic), Lenka KUČEROVÁ (203 Czech Republic), Kateřina HECZKOVÁ (203 Czech Republic), Zuzana DERFLEROVÁ BRÁZDOVÁ (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic).
Edition Genes and Nutrition, New Century Health Publishers, 2009, 1555-8932.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.112
RIV identification code RIV/00216224:14110/09:00036308
Organization unit Faculty of Medicine
UT WoS 000269912200009
Keywords (in Czech) ID ACE; obezita, polymorfismus; příjem potravy
Keywords in English ID ACE; obesity; polymorphism; food intake
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Julie Dobrovolná, Ph.D., učo 4805. Changed: 27/12/2009 00:15.
Abstract
Background: The aim of this study was to investigate the possible associations of insertion/deletion (ID) polymorphism in angiotensin-converting enzyme (ACE) (dbSNP rs 4646994) with the food intake and body composition in the Czech non-obese, obese and extremely obese populations. Material and methods: The total of 453 various-weighted individuals were enrolled in the study and were according to their BMI assigned into following subgroups: obese (BMI between 30 and 40), morbidly obese (BMI more than 40) and non-obese (20260g of carbohydrates/d, respectively. Conclusion: Based on our findings, the ID ACE polymorphism could represent a gene modulator of carbohydrate intake in morbidly obese Czech population; the strong significant effect of DD genotype was observed in the phenotypes of extreme obesity with the highest carbohydrate intake.
Abstract (in Czech)
U inzerčně-delečního polymorfismu (ID) v genu pro ACE jsme pozorovali signifikantní case-control rozdíly v alelických frekvencích a frekvencích genotypů mezi obézními a neobézními subjekty. Prevalence obezity byla signifikantně vyšší mezi subjekty s II genotypem (42%) než heterozygoty ID (37%) nebo DD homozygoty (36%). Tercilová analýza pak prokázala signifikantní efekt DD genotypu na příjem sacharidů ve skupině morbidně obézních jedinců.
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