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@article{841773,
author = {Grycová, Lenka and Dommisse, Roger and Pieters, Luc and Marek, Radek},
article_number = {11},
doi = {http://dx.doi.org/10.1002/mrc.2494},
keywords = {1H NMR;chemical shift;cryptolepine;isocryptolepine;neocryptolepine;isoneocryptolepine;malaria;pH;determination of pKa},
language = {eng},
issn = {0749-1581},
journal = {Magnetic Resonance in Chemistry},
title = {NMR determination of pKa values of indoloquinoline alkaloids},
url = {http://dx.doi.org/10.1002/mrc.2494},
volume = {47},
year = {2009}
}
TY - JOUR
ID - 841773
AU - Grycová, Lenka - Dommisse, Roger - Pieters, Luc - Marek, Radek
PY - 2009
TI - NMR determination of pKa values of indoloquinoline alkaloids
JF - Magnetic Resonance in Chemistry
VL - 47
IS - 11
SP - 977-981
EP - 977-981
PB - John Wiley & Sons
SN - 07491581
KW - 1H NMR;chemical shift;cryptolepine;isocryptolepine;neocryptolepine;isoneocryptolepine;malaria;pH;determination of pKa
UR - http://dx.doi.org/10.1002/mrc.2494
L2 - http://dx.doi.org/10.1002/mrc.2494
N2 - Malaria is one of the most serious global health problems. Isolating new therapeutic agents with potential antimalarial activity from natural sources or preparing such agents either semisynthetically or synthetically is one strategy for solving the problem of resistance constantly evolving to the drugs currently in use. For alkaloids, the acid-base dissociation constant, pKa, is an important characteristic, thought to be associated with biological activity. In this contribution, pKa values for several indoloquinoline alkaloids were determined by using 1H NMR spectroscopy in a mixture of solvents. The data were recalculated for water solutions using the correction factors reported previously. The structural dependence of the pKa values for cryptolepine and its isomers neocryptolepine, isocryptolepine and isoneocryptolepine as well as some substituted neocryptolepine derivatives is discussed.
ER -
GRYCOVÁ, Lenka, Roger DOMMISSE, Luc PIETERS a Radek MAREK. NMR determination of pKa values of indoloquinoline alkaloids. \textit{Magnetic Resonance in Chemistry}. John Wiley \&{} Sons, 2009, roč.~47, č.~11, s.~977-981. ISSN~0749-1581. Dostupné z: https://dx.doi.org/10.1002/mrc.2494.
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