Other formats:
BibTeX
LaTeX
RIS
@proceedings{842543, author = {Tanhäuserová, Veronika and Tomandl, Josef and Štěpánková, Soňa and Svojanovský, Jan and Krusová, Darja and Olšovský, Jindřich and Bělobrádková, Jana and Klepárník, Martin and Pácal, Lukáš and Kaňková, Kateřina}, booktitle = {Folia medica cassoviensia}, keywords = {nitric oxide; asymmetri dimethylarginine; reninangiotensin system;diabetic kidney disease}, language = {eng}, isbn = {978-80-7097-759-0}, title = {Relationships between levels of methylated arginine (ADMA), genetic variability of the reninangiontensin system and diabetic kidney disease}, year = {2009} }
TY - CONF ID - 842543 AU - Tanhäuserová, Veronika - Tomandl, Josef - Štěpánková, Soňa - Svojanovský, Jan - Krusová, Darja - Olšovský, Jindřich - Bělobrádková, Jana - Klepárník, Martin - Pácal, Lukáš - Kaňková, Kateřina PY - 2009 TI - Relationships between levels of methylated arginine (ADMA), genetic variability of the reninangiontensin system and diabetic kidney disease SN - 9788070977590 KW - nitric oxide KW - asymmetri dimethylarginine KW - reninangiotensin system;diabetic kidney disease N2 - L arginine and ADMA can both affect production of NO (regulation of renal hemodynamics). However, recent studies indicated that rather than inhibition of NO production by ADMA, pathologic activation of RAS and subsequent increase of oxidative stress (ACE ATIIR1 NAD(P)H oxidase pathway) play more significant pathogenic role. The aim of the study was to investigate i) relationship between plasma levels of L arginine and ADMA and stage of diabetic kidney disease and ii) relationship between ADMA, genetic variability in the RAS and stages of diabetic nephropathy. Significant correlation between the stage of kidney disease and L arginine (negative) and ADMA (positive) was ascertained (P < 0.05, Spearman). ADMA significantly correlated with both components of diabetic kidney disease, i.e. proteinuria and GFR (P < 0.05, Spearman). Multiple regression identified ADMA however, none of the RAS polymorphisms analysed, as a significant predictor of renal outcome (P < 0.01). ER -
TANHÄUSEROVÁ, Veronika, Josef TOMANDL, Soňa ŠTĚPÁNKOVÁ, Jan SVOJANOVSKÝ, Darja KRUSOVÁ, Jindřich OLŠOVSKÝ, Jana BĚLOBRÁDKOVÁ, Martin KLEPÁRNÍK, Lukáš PÁCAL and Kateřina KAŇKOVÁ. Relationships between levels of methylated arginine (ADMA), genetic variability of the reninangiontensin system and diabetic kidney disease. In \textit{Folia medica cassoviensia}. 2009. ISBN~978-80-7097-759-0.
|