KREJČÍ, Jana, Andrea HARNIČÁROVÁ, Denisa ŠTREITOVÁ, Roman HÁJEK, Luděk POUR, Stanislav KOZUBEK and Eva BÁRTOVÁ. Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation. Leukemia Research. England: Elsevier, 2009, vol. 33, No 11, p. 1490-1498. ISSN 0145-2126.
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Basic information
Original name Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation
Name in Czech Epigenetika mnohočetného myelomu po léčbě cytostatiky a radioterapií
Authors KREJČÍ, Jana (203 Czech Republic), Andrea HARNIČÁROVÁ (703 Slovakia), Denisa ŠTREITOVÁ (203 Czech Republic), Roman HÁJEK (203 Czech Republic, guarantor), Luděk POUR (203 Czech Republic), Stanislav KOZUBEK (203 Czech Republic) and Eva BÁRTOVÁ (203 Czech Republic).
Edition Leukemia Research, England, Elsevier, 2009, 0145-2126.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.358
RIV identification code RIV/00216224:14110/09:00028578
Organization unit Faculty of Medicine
UT WoS 000269870400013
Keywords (in Czech) mnohočetný myelom; acetylace histonu; metylace histonu; cytostatika
Keywords in English multiple myeloma; histone methylation; histone acetylation; cytostatics
Tags International impact, Reviewed
Changed by Changed by: Mgr. Anna Potáčová, Ph.D., učo 44190. Changed: 1/4/2010 16:46.
Abstract
Genetic and epigenetic changes in multiple myeloma (MM) correlate with the stage of the disease. Therefore, we investigated how cytostatics and gamma radiation influence MM-associated histone modifications. ChIP-PCR and ChIP-on-chip technologies were used to quantify H3K9 acetylation and H3K9 dimethylation at select loci in MM patients, lymphoblastoid ARH-77, and myeloma MOLP-8 cells.
Abstract (in Czech)
Genetické a epigenetické změny u mnohočetného myelomu korelují se stádiem onemocnění. V publikaci je popisováno jakým způsobem souvisejí modifikace histonů s léčbou cytostatiky a radioterapií, což bylo zjišťováno pomocí ChIP-PCR a ChIP-on-chip technologií.
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