Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Zuzana DERFLEROVÁ BRÁZDOVÁ and Anna VAŠKŮ. Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. British Journal of Nutrition. Cambridge: Cambridge University Press, 2009, vol. 2009, No 14, p. 1-8. ISSN 0007-1145.

Basic information

Original name

Genotype 3 nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake

Name in Czech

Genotypově-nutriční asociace v populaci četných polymorfismů v genech souvisejících s obezitou se skladbou stravy a časovou strukturou příjmu potravy

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor, belonging to the institution), Petr BIENERT (203 Czech Republic), Josef TOMANDL (203 Czech Republic, belonging to the institution), Martin FOREJT (203 Czech Republic, belonging to the institution), Zuzana DERFLEROVÁ BRÁZDOVÁ (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

British Journal of Nutrition, Cambridge, Cambridge University Press, 2009, 0007-1145

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.446

RIV identification code

RIV/00216224:14110/09:00036606

Organization unit

Faculty of Medicine

UT WoS

000274689400008

Keywords (in Czech)

adipokin; polymorfismus; obezita; skladba potravy

Keywords in English

Adipokine; polymorphism; obesity; dietary composition

Tags

International impact, Reviewed

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Abstract

V originále

Individual dietary composition can either enhance or suppress the development of obesity and the selection and proportion of macronutrients in the diet seems to have a heritable component. In this study, we focused on dietary composition as the typical obesity-related trait and we investigated selected genetic variations in leptin (LEP), leptin receptor (LEPR), adiponectin (ADIPOQ), interleukin 6 (IL6) and proopiomelanocortin (POMC). The total of 409 individuals of Czech Caucasian origin were enrolled into this study and the 7-day food records were obtained from the study subjects along with selected anthropometric measurements. The LEP +19A/G polymorphism served as an independent predictor for BMI, % of body fat and skin fold thickness and significantly affected the time structure of the daily energy intake. The POMC RsaI polymorphism was associated with the % of body fat. ADIPOQ 45 T/G polymorphism was associated with the thickness of the subscapular skin fold. The LEPR Gln223Arg polymorphism was associated with multiple parameters, including diastolic blood pressure, meal sizes during the day and plasma adiponectin levels. In a separate analysis, sObR plasma levels and leptin/sObR ratio were significantly correlated with systolic blood pressure (beta = -0.66, p = 0.002; resp. beta = -1.23, p = 0.02) and sObR plasma levels also served as an independent predictor for diastolic blood pressure (beta = -0.50, p = 0.04). To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence time structure of food intake.

In Czech

V dané studii popisujeme v populaci četné alelické varianty asociované se specifickým stravovacím chování a antropometrickými znaky souvisejícími s obezitou. V rámci studie byly dále identifikovány alelické varianty, které signifikantně ovlivňují časovou strukturu příjmu potravy.