Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ. Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma. In Journal of Investigative Dermatology. 2009th ed. USA: Nature Publishing Group, Macmillan Publishers Ltd, 2009, p. S51-51, 1 pp. ISSN 0022-202X.

Basic information

• Original name: Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma
• Name in Czech: Genetické polymorfismy v genu pro endokanabinoidní receptor typu I (CNR1): asociace s vnímavostí vůči kožnímu T-lymfomu
• Authors: VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ.
• Edition: 2009. vyd. USA, Journal of Investigative Dermatology, p. S51-51, 1 pp. 2009.
• Publisher: Nature Publishing Group, Macmillan Publishers Ltd

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30216 Dermatology and venereal diseases
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 5.543
• Organization unit: Faculty of Medicine
• ISSN: 0022-202X
• Keywords (in Czech): kožní T-lymfom; endokanabinoidy; SNP; asociační studie
• Keywords in English: T cell lymphoma; endocannabinoids; SNP; association study
• Tags: International impact, Reviewed

Abstract

Endocannabinoids are lipid mediators thought to modulate central and peripheral neural functions. Recently, the overexpressionof the central and peripheral cannabinoid receptors CB1 and CB2 was reported in various types of lymphomas. Therefore, the aim of the study was to investigate possible associations of 3 common SNPs in CNR1 gene (rs1049343, rs12720071 and rs806368) with cutaneous T-cell lymphoma. The total of 97 patients with CTCL were recruited for the study along with 258 healthy Czech individuals of similar age and gender distribution. No significant differences in genotype distributions as well as allele frequencies were observed between the CTCL cases and controls. Five common haplotypes in the CNR1 gene were identified, whereas the frequencies of the haplotypes differed significantly betweent the cases and the controls (Phap less than 0.001). In the multivariate modelling, the CNR1 4895 C/T (rs806368) expressed an independent prediction role for the CTCL staging (beta = -0.27, P = 0.05). Based on our results, the CNR1 gene could be considered a susceptibility marker for cutaneous T-cell lymphoma.

Abstract (in Czech)

Endokanabinoidy jsou mediátory lipidové povahy, které jsou považovány za významné modulátory centrálních i periferních nervových funkcí. Na základě výsledků této studie se domníváme, že CNR1 gen může být považován za gen vnímavosti pro kožní T-lymfom.