Cognitive deficits in the euthymic phase of unipolar depression

PREISS, Marek, Hana PŘIKRYLOVÁ KUČEROVÁ, Jiří LUKAVSKÝ a Hana ŠTĚPÁNKOVÁ. Cognitive deficits in the euthymic phase of unipolar depression. Psychiatry Research. Netherlands: Elsevier Ireland, 2008, roč. 169, č. 169, s. 235-239. ISSN 0165-1781.

Základní údaje

• Originální název: Cognitive deficits in the euthymic phase of unipolar depression
• Název česky: Kognitivní deficit u pacientů s unipolární depresivní poruchou
• Název anglicky: Cognitive deficits in the euthymic phase of unipolar depression
• Autoři: PREISS, Marek (203 Česká republika), Hana PŘIKRYLOVÁ KUČEROVÁ (203 Česká republika, garant), Jiří LUKAVSKÝ (203 Česká republika) a Hana ŠTĚPÁNKOVÁ (203 Česká republika).
• Vydání: Psychiatry Research, Netherlands, Elsevier Ireland, 2008, 0165-1781.

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Článek v odborném periodiku
• Obor: 30000 3. Medical and Health Sciences
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Impakt faktor: Impact factor: 2.666
• Kód RIV: RIV/00216224:14110/08:00036703
• Organizační jednotka: Lékařská fakulta
• UT WoS: 000271143500008
• Klíčová slova česky: depresivní porucha-remise-kognitivní funkce-průběh onemocnění- funkční stav
• Klíčová slova anglicky: Major depressive episode-remission-cognitive function-course of illness-outcome
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

Although neuropsychological deficits have been reported in patients with major depressive disorder (MDD) during an acute episode, relatively little is known about the persistence of these deficits in remission. This study investigated the performance of attention, executive function and verbal memory during remission from unipolar depressive episodes. We tested the hypothesis that outpatients do not differ in cognitive variables from controls. We did this using a well-defined outpatient sample, consisting of medicated and unmedicated patients, with a history of MDD. Ninety-seven subjects with MDD in remission ranging from young to old were compared with 97 healthy control subjects. Both samples were balanced for age, gender, and education levels. The Auditory Verbal Learning Test (AVLT) and the Trail Making Test (TMT) were used. Patients with remitted MDD, in comparison with controls, were impaired on tasks of attention, executive function and verbal memory. The individual level of depressive symptoms was not related to the cognitive performance. Small- to medium-sized significant correlations exist between cognitive test variables (as represented by Trail Making B and AVLT delayed recall) and level of depressive symptomatology (as measured by MADRS or BDI-II) in the total sample, indicating that higher levels of depressive symptomatology are associated with lower cognitive function. These findings suggest deficits in attention and delayed verbal recall can serve as an indicator for MDD in outpatients.

Anotace anglicky

Although neuropsychological deficits have been reported in patients with major depressive disorder (MDD) during an acute episode, relatively little is known about the persistence of these deficits in remission. This study investigated the performance of attention, executive function and verbal memory during remission from unipolar depressive episodes. We tested the hypothesis that outpatients do not differ in cognitive variables from controls. We did this using a well-defined outpatient sample, consisting of medicated and unmedicated patients, with a history of MDD. Ninety-seven subjects with MDD in remission ranging from young to old were compared with 97 healthy control subjects. Both samples were balanced for age, gender, and education levels. The Auditory Verbal Learning Test (AVLT) and the Trail Making Test (TMT) were used. Patients with remitted MDD, in comparison with controls, were impaired on tasks of attention, executive function and verbal memory. The individual level of depressive symptoms was not related to the cognitive performance. Small- to medium-sized significant correlations exist between cognitive test variables (as represented by Trail Making B and AVLT delayed recall) and level of depressive symptomatology (as measured by MADRS or BDI-II) in the total sample, indicating that higher levels of depressive symptomatology are associated with lower cognitive function. These findings suggest deficits in attention and delayed verbal recall can serve as an indicator for MDD in outpatients.

Návaznosti

• 1M0517, projekt VaV: Název: Centrum neuropsychiatrických studií 2005-2009 (Neurobiologie v klinické aplikaci)