Detailed Information on Publication Record
2009
Haloperidol moderately inhibits cardiovascular L-type calcium current
TARABOVÁ, Bohumila, Marie NOVÁKOVÁ and Ľubica LACINOVÁBasic information
Original name
Haloperidol moderately inhibits cardiovascular L-type calcium current
Name in Czech
Haloperidol mírně inhibuje kardiovaskulární L-typ vápníkového proudu
Authors
TARABOVÁ, Bohumila (703 Slovakia), Marie NOVÁKOVÁ (203 Czech Republic, guarantor) and Ľubica LACINOVÁ (703 Slovakia)
Edition
General Physiology and Biophysics, Bratislava, Slovak Academy of Sciences, 2009, 0231-5882
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.741
RIV identification code
RIV/00216224:14110/09:00037292
Organization unit
Faculty of Medicine
UT WoS
000272335700005
Keywords (in Czech)
Haloperidol;kardiomyocyty;akční potenciál;L-typ vápníkového proudu
Keywords in English
Haloperidol;cardiomyocytes;Action potential;L-type calcium current
Tags
International impact, Reviewed
Změněno: 26/11/2009 09:29, prof. MUDr. Marie Nováková, Ph.D.
V originále
Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice variants of the channel expressed in HEK 293 cells. Haloperidol inhibited L-type calcium current in a concentration-dependent manner with a threshold of 1 nmol/l. Inhibition was not accompanied by alteration of current waveform or by shift of current-voltage relation. In a current clamp haloperidol suppressed action potential generation. 1 micromol/l of the drug shortened the action potential duration in part of the cells and suppressed fully action potential in other cells. Moderate inhibition of the L-type calcium channels by haloperidol might cause shortening of action potential.
In Czech
Byl zkoumán efekt haloperidolu na L-typ CaV1.2 kanálu metodou whole cell patch-clamp za použití kalcia jako nosiče, a to v kardiomyocytech a na modelu HEK293 buněk s exprimovanými vápníkovými kanály. Byla nalezena mírná inhibice L-typu vápníkových kanálů haloperidolem a také zkrácení akčního potenciálu.
Links
| MSM0021622402, plan (intention) |
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