TARABOVÁ, Bohumila, Marie NOVÁKOVÁ a Ľubica LACINOVÁ. Haloperidol moderately inhibits cardiovascular L-type calcium current. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2009, roč. 28, č. 3, s. 249-259. ISSN 0231-5882. |
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@article{856455, author = {Tarabová, Bohumila and Nováková, Marie and Lacinová, Ľubica}, article_location = {Bratislava}, article_number = {3}, keywords = {Haloperidol;cardiomyocytes;Action potential;L-type calcium current}, language = {eng}, issn = {0231-5882}, journal = {General Physiology and Biophysics}, title = {Haloperidol moderately inhibits cardiovascular L-type calcium current}, volume = {28}, year = {2009} }
TY - JOUR ID - 856455 AU - Tarabová, Bohumila - Nováková, Marie - Lacinová, Ľubica PY - 2009 TI - Haloperidol moderately inhibits cardiovascular L-type calcium current JF - General Physiology and Biophysics VL - 28 IS - 3 SP - 249-259 EP - 249-259 PB - Slovak Academy of Sciences SN - 02315882 KW - Haloperidol;cardiomyocytes;Action potential;L-type calcium current N2 - Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice variants of the channel expressed in HEK 293 cells. Haloperidol inhibited L-type calcium current in a concentration-dependent manner with a threshold of 1 nmol/l. Inhibition was not accompanied by alteration of current waveform or by shift of current-voltage relation. In a current clamp haloperidol suppressed action potential generation. 1 micromol/l of the drug shortened the action potential duration in part of the cells and suppressed fully action potential in other cells. Moderate inhibition of the L-type calcium channels by haloperidol might cause shortening of action potential. ER -
TARABOVÁ, Bohumila, Marie NOVÁKOVÁ a Ľubica LACINOVÁ. Haloperidol moderately inhibits cardiovascular L-type calcium current. \textit{General Physiology and Biophysics}. Bratislava: Slovak Academy of Sciences, 2009, roč.~28, č.~3, s.~249-259. ISSN~0231-5882.
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