HARNIČAROVÁ, Andrea, Gabriela GALIOVÁ, Soňa LEGARTOVÁ, Stanislav KOZUBEK, Pavel MATULA and Eva BÁRTOVÁ. Chromocentre integrity and epigenetic marks. Journal of Structural Biology. United States: Academic Press, Elsevier Inc., 2010, vol. 169, No 1, p. 124-133. ISSN 1047-8477. Available from: https://dx.doi.org/10.1016/j.jsb.2009.09.007.
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Basic information
Original name Chromocentre integrity and epigenetic marks
Name in Czech Integrita chromocenter a epigenetické značky
Authors HARNIČAROVÁ, Andrea (703 Slovakia), Gabriela GALIOVÁ (203 Czech Republic), Soňa LEGARTOVÁ (703 Slovakia), Stanislav KOZUBEK (203 Czech Republic), Pavel MATULA (203 Czech Republic, guarantor, belonging to the institution) and Eva BÁRTOVÁ (203 Czech Republic).
Edition Journal of Structural Biology, United States, Academic Press, Elsevier Inc. 2010, 1047-8477.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.500
RIV identification code RIV/00216224:14330/10:00051222
Organization unit Faculty of Informatics
Doi http://dx.doi.org/10.1016/j.jsb.2009.09.007
UT WoS 000274043100015
Keywords (in Czech) SUV39h; methylace histonu; epigenetika
Keywords in English SUV39h; epigenetics; histone methylation
Tags International impact, Reviewed
Changed by Changed by: RNDr. Pavel Šmerk, Ph.D., učo 3880. Changed: 18/4/2012 09:28.
Abstract
The epigenetic modification of histones dictates the formation of euchromatin and heterochromatin domains. We studied the effects of a deficiency of histone methyltransferase, SUV39h, and trichostatin A-dependent hyperacetylation on the structural stability of centromeric clusters, called chromocentres. We did not observe the expected disintegration of chromocentres, but both SUV39h deficiency and hyperacetylation in SUV39h+/+ cells induced the re-positioning of chromocentres closer to the nuclear periphery.
Abstract (in Czech)
Epigenetické modifikace histonů určují formování euchromatinových a heterochromatinových domén. Studovali jsme efekt nedostatku histon metyltransferasy, SUV39h a trichostatin A dependentní hyperacetylace na struktirální stabilitu klastrů centromer, zvaných chromocentra. Naše výsledky dokazují význam epigentckých značek pro integritu chromocenter.
Links
LC535, research and development projectName: Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii
Investor: Ministry of Education, Youth and Sports of the CR, Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii
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