KREJČÍ, Jana, Radka UHLÍŘOVÁ, Gabriela GALIOVÁ, Stanislav KOZUBEK, Jana ŠMIGOVÁ and Eva BÁRTOVÁ. Genome-Wide Reduction in H3K9 Acetylation During Human Embryonic Stem Cell Differentiation. Journal of cellular physiology. United States: Wiley-Liss, 2009, vol. 219, No 3, p. 677-687. ISSN 0021-9541.
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Basic information
Original name Genome-Wide Reduction in H3K9 Acetylation During Human Embryonic Stem Cell Differentiation
Name in Czech Širokogenomová redukce v H3K9 acetylaci během diferenciace lidské embryonální kmenové buňky
Authors KREJČÍ, Jana (203 Czech Republic), Radka UHLÍŘOVÁ (203 Czech Republic), Gabriela GALIOVÁ (203 Czech Republic), Stanislav KOZUBEK (203 Czech Republic, guarantor), Jana ŠMIGOVÁ (203 Czech Republic) and Eva BÁRTOVÁ (203 Czech Republic).
Edition Journal of cellular physiology, United States, Wiley-Liss, 2009, 0021-9541.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.586
RIV identification code RIV/00216224:14310/09:00028663
Organization unit Faculty of Science
UT WoS 000265547900020
Keywords (in Czech) acetylace; chromatin; epigenetika; H3K9; kmenová buňka
Keywords in English acetylation; stem cell; H3K9; epigenetics
Tags International impact, Reviewed
Changed by Changed by: Mgr. Anna Potáčová, Ph.D., učo 44190. Changed: 1/4/2010 17:05.
Abstract
In this study, we analyzed H3K9 acetylation, an epigenetic mark associated with transcriptionally active chromatin, during endoderm-like differentiation of hESCs. ChIP-on-chip analysis revealed that differentiation results in a genome-wide decrease in promoter H3K9 acetylation.
Abstract (in Czech)
V této studii jsme analyzovali H3K9 acetylace, epigenetickou značku spojenou s transkripčně aktivním chromatinem. ChIP-on-chip analýza ukázala, že diferenciace ústí v širokogenomový pokles acetylace promoteru H3K9.
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